Evidence map›Paper›PMID 39256776›Full record

ArticleActa neuropathologica communications2024

Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization.

Nan Lian, Fangzhou Li, Cheng Zhou, Yan Yin, Yi Kang, Kaiteng Luo, Su Lui, Tao Li, Peilin Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Osteoclast-Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nan Lian *Laboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China.
Fangzhou Li *Department of Anesthesiology, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Cheng ZhouDepartment of Anesthesiology, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Yan YinDepartment of Pain Management, West China Hospital of Sichuan University, Chengdu, 610041, China.
Yi KangDepartment of Anesthesiology, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Kaiteng LuoLaboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China.
Su LuiHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tao LiLaboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China. scutaoli1981@scu.edu.cn.
Peilin LuLaboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China. peilinlyu@qq.com.ORCID 0009-0002-2786-3730

Funding

National Key R&D Program of China 2022YFC2009900National Key R&D Program of China 2022YFC2009901National Natural Science Foundation of China 81801117Sichuan Science and Technology Program 2023NSFSC1734Sichuan Science and Technology Program 2023ZYD0168Sichuan Science and Technology Program 2024NSFSC0616STI2030-Major Projects 2021ZD0201904
6 · The paper itself

Abstract

Maladaptive changes of metabolic patterns in the lumbar dorsal root ganglion (DRG) are critical for nociceptive hypersensitivity genesis. The accumulation of branched-chain amino acids (BCAAs) in DRG has been implicated in mechanical allodynia and thermal hyperalgesia, but the exact mechanism is not fully understood. This study aimed to explore how BCAA catabolism in DRG modulates pain sensitization. Wildtype male mice were fed a high-fat diet (HFD) for 8 weeks. Adult PP2Cm

Indexed as

Amino Acids, Branched-ChainDiet, High-FatGanglia, SpinalHyperalgesiaAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, CCR5TRPA1 Cation ChannelAmino Acids, Branched-ChainReceptors, CCR5TRPA1 Cation ChannelTrpa1 protein, mouseBCAAsCCL5/CCR5 axisDRGPain sensitizationTRPA1

Identifiers

PMID39256776
PMCPMC11385486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.