Evidence map›Paper›PMID 39256775›Full record

ArticleClinical epigenetics2024

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain.

Danni A Gadd, Hannah M Smith, Donncha Mullin, Ola Chybowska, Robert F Hillary, Dorien M Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Proteomic biomarkers of cognitive function,medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Danni A GaddCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Hannah M SmithCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Donncha MullinDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Ola ChybowskaCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Robert F HillaryCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Dorien M KimenaiBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Elena BernabeuCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Yipeng ChengCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Chloe Fawns-RitchieCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Danielle PageDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Adele TaylorDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Janie CorleyDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Maria Del C Valdés-HernándezDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Susana Muñoz ManiegaDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Mark E BastinDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Joanna M WardlawDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Rosie M WalkerCentre for Clinical Brain Sciences, Edinburgh Imaging and UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Kathryn L EvansCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Andrew M McIntoshDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Caroline HaywardCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Tom C RussDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Sarah E HarrisDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Paul WelshSchool of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, UK.
Naveed SattarSchool of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, UK.
Simon R CoxDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.

Funding

AORTIC PROTEOGLYCANS AND ATHEROSCLEROSISR01HL025161 · NHLBI · WAKE FOREST UNIVERSITY · PI WAGNER, WILLIAM D · 1986 to 1996
–
Alzheimer's Society AS-PG-19b-010British Heart Foundation Intermediate Basic Science Research Fellowship FS/IBSRF/23/25161Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6Scottish funding council HR03006Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society 221890/Z/20/ZUK Dementia Research Institute Ltd which is funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK Institute award no. UKDRI - Edin002, DRIEdi17/18, and MRC MC_PC_17113Wellcome TrustWellcome Trust 104036/Z/14/ZWellcome Trust 108890/Z/15/ZWellcome Trust 218493/Z/19/ZWellcome Trust 221890/Z/20/Z
6 · The paper itself

Abstract

backgroundPlasma growth differentiation factor 15 (GDF15) and N-terminal proB-type natriuretic peptide (NT-proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proBNP may provide new routes for risk stratification.

resultsIn the Generation Scotland cohort (N ≥ 16,963), GDF15 levels were associated with incident dementia, ischaemic stroke and type 2 diabetes, whereas NT-proBNP levels were associated with incident ischaemic heart disease, ischaemic stroke and type 2 diabetes (all P

conclusionsEpiScores for serum levels of GDF15 and Nt-proBNP associate with body and brain health traits. These EpiScores are provided as potential tools for disease risk stratification.

Indexed as

BiomarkersDiabetes Mellitus, Type 2DNA MethylationGrowth Differentiation Factor 15Natriuretic Peptide, BrainPeptide FragmentsAgedBayes TheoremCohort StudiesDementiaEpigenesis, GeneticFemaleHumansIschemic StrokeMaleMiddle AgedBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)BrainCardiovascularDementiaDiabetesDNA methylationEpigeneticGDF15NT-proBNPRisk stratificationStroke

Identifiers

PMID39256775
PMCPMC11389299

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.