Evidence map›Paper›PMID 39256758›Full record

ArticleBMC biology2024

FgCWM1 modulates TaNDUFA9 to inhibit SA synthesis and reduce FHB resistance in wheat.

Yazhou Zhang, Danyu Yao, Xinyu Yu, Xinyao Cheng, Lan Wen, Caihong Liu, Qiang Xu, Mei Deng, Qiantao Jiang, Pengfei Qi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Unveiling Metabolic Capability and Growth Adaptation ofInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yazhou Zhang *State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Danyu Yao *National Engineering Laboratory of Crop Molecular Breeding, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Xinyu YuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Xinyao ChengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Lan WenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Caihong LiuInstitute of Phytopathology, Land Use and Nutrition, Research Centre for BioSystems, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, Giessen, 35392, Germany.
Qiang XuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Mei DengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Qiantao JiangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Pengfei QiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Yuming WeiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, and, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. ymwei@sicau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFusarium head blight (FHB) significantly impacts wheat yield and quality. Understanding the intricate interaction mechanisms between Fusarium graminearum (the main pathogen of FHB) and wheat is crucial for developing effective strategies to manage and this disease. Our previous studies had shown that the absence of the cell wall mannoprotein FgCWM1, located at the outermost layer of the cell wall, led to a decrease in the pathogenicity of F. graminearum and induced the accumulation of salicylic acid (SA) in wheat. Hence, we propose that FgCWM1 may play a role in interacting between F. graminearum and wheat, as its physical location facilitates interaction effects.

resultsIn this study, we have identified that the C-terminal region of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 (NDUFA9) could interact with FgCWM1 through the yeast two-hybrid assay. The interaction was further confirmed through the combination of Co-IP and BiFC analyses. Consistently, the results of subcellular localization indicated that TaNDUFA9 was localized in the cytoplasm adjacent to the cell membrane and chloroplasts. The protein was also detected to be associated with mitochondria and positively regulated complex I activity. The loss-of-function mutant of TaNDUFA9 exhibited a delay in flowering, decreased seed setting rate, and reduced pollen fertility. However, it exhibited elevated levels of SA and increased resistance to FHB caused by F. graminearum infection. Meanwhile, inoculation with the FgCWM1 deletion mutant strain led to increased synthesis of SA in wheat.

conclusionsThese findings suggest that TaNDUFA9 inhibits SA synthesis and FHB resistance in wheat. FgCWM1 enhances this inhibition by interacting with the C-terminal region of TaNDUFA9, ultimately facilitating F. graminearum infection in wheat. This study provides new insights into the interaction mechanism between F. graminearum and wheat. TaNDUFA9 could serve as a target gene for enhancing wheat resistance to FHB.

Indexed as

Disease ResistanceFusariumPlant DiseasesPlant ProteinsSalicylic AcidTriticumPlant ProteinsSalicylic AcidCell wall mannoproteinComplex I subunitFusarium head blightInteractionWheat resistance

Identifiers

PMID39256758
PMCPMC11389325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.