ArticleNature metabolism2024
Years of endurance exercise training remodel abdominal subcutaneous adipose tissue in adults with overweight or obesity.
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of concurrent training on fat mass and its distribution in individuals with overweight or obesity: a systematic review, meta-analysis, and exploratory regression analysis.BMC public health · 2026Pooled it
- ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis.The Journal of clinical investigation · 2025Trial
- Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans.Cell reports. Medicine · 2026Article
- Exercise training is associated with changes in adipocyte size and lipid metabolism in older women: cross-sectional and longitudinal study.BMC geriatrics · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- A scalable, hyperstable intelligent fibre velocimeter for dynamic digitization of resistance training.National science review · 2026Article
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- Exercise modulates redox homeostasis in cardiovascular and metabolic diseases: from bench to clinic.Cardiovascular diabetology · 2026Review
- Burden and causes due to high fasting plasma glucose in China from 1990 to 2021: a systematic analysis and comparison with the global burden.BMC public health · 2026Article
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex.Cellular and molecular neurobiology · 2025Article
- Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China.Journal of sport and health science · 2025Article
- An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS).Journal of molecular endocrinology · 2025Article
- Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity.The Journal of physiology · 2025Article
- Exercise intensity modulates the human plasma secretome and interorgan communication.bioRxiv : the preprint server for biology · 2025Article
- Impact of body composition on fragility fractures in US elderly adults: a population-based study.BMC geriatrics · 2025Article
- Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers.bioRxiv : the preprint server for biology · 2025Article
- Risk factors for advance stage cardiovascular-renal-metabolic syndrome in patients with early-onset type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Abnormalities in the structure and metabolic function of abdominal subcutaneous adipose tissue (aSAT) underlie many obesity-related health complications. Endurance exercise improves cardiometabolic health in adults with overweight or obesity, but the effects of endurance training on aSAT are unclear. We included male and female participants who were regular exercisers with overweight or obesity who exercised for >2 years, and cross-sectionally compared them with well-matched non-exercisers with overweight or obesity. Here we show aSAT from exercisers has a higher capillary density, lower Col6a abundance and fewer macrophages compared with non-exercisers. This is accompanied by a greater abundance of angiogenic, ribosomal, mitochondrial and lipogenic proteins. The abundance of phosphoproteins involved in protein translation, lipogenesis and direct regulation of transcripts is also greater in aSAT collected from exercisers. Exploratory ex vivo experiments demonstrate greater angiogenic capacity and higher lipid-storage capacity in samples cultured from aSAT collected from exercisers versus non-exercisers. Regular exercise may play a role in remodelling aSAT structure and proteomic profile in ways that may contribute to preserved cardiometabolic health.
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