Evidence map›Paper›PMID 39256495›Full record

ArticleScientific reports2024

Synthesis, biological evaluation and molecular modeling studies of methyl indole-isoxazole carbohydrazide derivatives as multi-target anti-Alzheimer's agents.

Aida Iraji, Parisa Nikfar, Mohammad Nazari Montazer, Mona Karimi, Najmeh Edraki, Mina Saeedi, Seyedeh Sara Mirfazli

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Novel cinnamic acid-basedRSC advances · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aida IrajiDepartment of Persian Medicine, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Parisa NikfarDepartment of Medicinal Chemistry, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Nazari MontazerEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mona KarimiDepartment of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Najmeh EdrakiMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mina SaeediMedicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. m-saeedi@tums.ac.ir.
Seyedeh Sara MirfazliDepartment of Medicinal Chemistry, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. saramirfazli@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects the elderly population globally and there is an urgent demand for developing novel anti-AD agents. In this study, a new series of indole-isoxazole carbohydrazides were designed and synthesized. The structure of all compounds was elucidated using spectroscopic methods including FTIR,

Indexed as

AcetylcholinesteraseAlzheimer DiseaseButyrylcholinesteraseCholinesterase InhibitorsIndolesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBinding SitesHumansHydrazinesIsoxazolesKineticsModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAcetylcholinesteraseAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanButyrylcholinesterasecarbohydrazideCholinesterase InhibitorsHydrazinesIndolesIsoxazolesAcetylcholinesteraseBACE1ButyrylcholinesteraseIndoleIsoxazoleMolecular dynamicSynthesis

Identifiers

PMID39256495
PMCPMC11387822

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.