Evidence map›Paper›PMID 39256483›Full record

ArticleScientific reports2024

Annual variation of estimated glomerular filtration rate in health check-ups associated with end-stage kidney disease.

Sadanori Okada, Yuichi Nishioka, Koshiro Kanaoka, Miyuki Koizumi, Fumika Kamitani, Hiroki Nakajima, Yukako Kurematsu, Sinichiro Kubo, Tomoya Myojin, Tatsuya Noda and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sadanori Okada *Department of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. saokada@naramed-u.ac.jp.
Yuichi Nishioka *Department of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. y_n@naramed-u.ac.jp.
Koshiro KanaokaDepartment of Medical and Information Management, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, Japan.
Miyuki KoizumiDepartment of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Fumika KamitaniDepartment of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Hiroki NakajimaDepartment of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Yukako KurematsuDepartment of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Sinichiro KuboDepartment of Public Health, Health Management, and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Tomoya MyojinDepartment of Public Health, Health Management, and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Tatsuya NodaDepartment of Public Health, Health Management, and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Yoshihiko SaitoNara Prefecture Seiwa Medical Center, 1-14-16 Mimuro, Sango, Ikoma-gun, Nara, Japan.
Tomoaki ImamuraDepartment of Public Health, Health Management, and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Yutaka TakahashiDepartment of Diabetes and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Funding

Japan Society for the Promotion of Science 21K10451Japan Society for the Promotion of Science,Japan 22H03355Japan Society for the Promotion of Science,Japan 23H00507the Health Science and Labor Research Grants 21IA1006
6 · The paper itself

Abstract

Estimated glomerular filtration rate (eGFR) variation is associated with end-stage kidney disease (ESKD) development in patients with chronic kidney disease; whether annual variations in eGFR at health check-ups is associated with ESKD risk in the general population is unclear. We conducted a retrospective cohort study using Japanese national medical insurance claims from 2013 to 2020. Individuals who had their eGFR levels measured three times in annual health check-ups were included (N = 115,191), and the coefficient of variation of eGFR (CVeGFR) was calculated from 3-point eGFR. The end-point was ESKD as reported in the claims data. We analyzed the association between CVeGFR and ESKD incidence after adjusting for conventional ESKD risk factors. The CVeGFR median distribution was 5.7% (interquartile range: 3.5-8.5%). During a median follow-up period of 3.74 years, 164 patients progressed to ESKD. ESKD incidence was significantly higher in the highest quartile group (CVeGFR ≥ 8.5%) than in the other groups (P < 0.0001). After adjusting for risk factors, individuals with CVeGFR ≥ 8.5% had a significantly high ESKD incidence (adjusted hazard ratio: 3.01; 95% CI 2.14-4.30). High CVeGFR in annual health check-ups was associated with high ESKD incidence, independent of its other conventional risk factors, in the general population.

Indexed as

Glomerular Filtration RateKidney Failure, ChronicAdultAgedDisease ProgressionFemaleHumansIncidenceJapanMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsAnnual health check-upCoefficient of variation of estimated glomerular filtration rateEnd-stage kidney diseaseMedical insurance claims data

Identifiers

PMID39256483
PMCPMC11387403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.