Evidence map›Paper›PMID 39256434›Full record

ArticleScientific reports2024

Giant pyramidal neurons of the primary motor cortex express vasoactive intestinal polypeptide (VIP), a known marker of cortical interneurons.

Sadaf Teymornejad, Katrina H Worthy, Marcello G P Rosa, Nafiseh Atapour

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sadaf TeymornejadDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC, 3800, Australia.
Katrina H WorthyDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC, 3800, Australia.
Marcello G P RosaDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC, 3800, Australia.
Nafiseh AtapourDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC, 3800, Australia. nafiseh.atapour@monash.edu.ORCID 0000-0002-8773-9283

Funding

National Health and Medical Research Council APP1194206National Health and Medical Research Council APP2019011
6 · The paper itself

Abstract

Vasoactive intestinal polypeptide (VIP) is known to be present in a subclass of cortical interneurons. Here, using three different antibodies, we demonstrate that VIP is also present in the giant layer 5 pyramidal (Betz) neurons which are characteristic of the limb and axial representations of the marmoset primary motor cortex (cytoarchitectural area 4ab). No VIP staining was observed in smaller layer 5 pyramidal cells present in the primary motor facial representation (cytoarchitectural area 4c), or in the premotor cortex (e.g. the caudal subdivision of the dorsal premotor cortex, A6DC), indicating the selective expression of VIP in Betz cells. VIP in Betz cells was colocalized with neuronal specific marker (NeuN) and a calcium-binding protein parvalbumin (PV). PV also intensely labelled axon terminals surrounding Betz cell somata. VIP-positive interneurons were more abundant in the superficial cortical layers and constituted about 5-7% of total cortical neurons, with the highest density observed in area 4c. Our results demonstrate the expression of VIP in the largest excitatory neurons of the primate cortex, which may offer new functional insights into the role of VIP in the brain, and provide opportunities for genetic manipulation of Betz cells.

Indexed as

CallithrixInterneuronsMotor CortexPyramidal CellsVasoactive Intestinal PeptideAnimalsBiomarkersFemaleMaleParvalbuminsBiomarkersParvalbuminsVasoactive Intestinal PeptideBetz cellsInhibitory neuronsLayer 5 pyramidal cellsMarmosetPrimary motor cortexVasoactive intestinal polypeptide

Identifiers

PMID39256434
PMCPMC11387615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.