ArticleNature communications2024
A secreted fungal laccase targets the receptor kinase OsSRF3 to inhibit OsBAK1-OsSRF3-mediated immunity in rice.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An apoplastic effector Uv7366 contributes toVirulence · 2026Article
- A Fungal Glycoside Hydrolase From Colletotrichum asianum Mini-Chromosomes Targets Host Chitinase to Suppress Plant Immunity.Molecular plant pathology · 2026Article
- Evolutionary Characteristics of the Rice SnRK2 Family and ABI5 Interaction Analysis Reveal Their Key Regulatory Role in Osmotic Stress Signaling.International journal of molecular sciences · 2026Article
- A fungal subtilase-like protease SBT1 blocks rice immunity by erasing the MAPKKKα signaling node.Science advances · 2026Article
- Structure of the Arabidopsis receptor kinase SRF6 ectodomain determined from crystals obtained using the LRR crystallization screen.Acta crystallographica. Section D, Structural biology · 2026Article
- The multifaceted physiological roles of fungal laccases.Communications biology · 2026Review
- Rice false smut fungus hijacks rice lipid signalling to manipulate floret development and immunity.Nature plants · 2026Article
- Article
- False smut of rice: integrating molecular pathogenicity and epidemiology for next-generation disease management.Frontiers in fungal biology · 2026Review
- A Secretory Protein Laccase lac8 From Pathogenic Fungi Activates Plant Protein 14-3-3 and Leucine-Rich Repeat Receptor-Like Protein LRR-RLP1 to Trigger Mango Immunity.Molecular plant pathology · 2025Article
- Natural Allelic Variations in IbCHYR1-IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Transcriptomic and metabolomic analyses unravel the different pathogenic mechanisms ofFrontiers in microbiology · 2025Article
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12 authors.
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Abstract
The identification effector targets and characterization of their functions are crucial for understanding pathogen infection mechanisms and components of plant immunity. Here, we identify the effector UgsL, a ustilaginoidin synthetase with a key role in regulating virulence of the rice false smut fungus Ustilaginoidea virens. Heterologous expression of UgsL in rice (Oryza sativa) enhances plant susceptibility to multiple pathogens, and host-induced gene silencing of UgsL enhances plant resistance to U. virens, indicating that UgsL inhibits rice immunity. UgsL interacts with STRUBBELIG RECEPTOR KINASE 3 (OsSRF3). Genome editing and overexpression of OsSRF3 demonstrate that OsSRF3 plays a pivotal role in the resistance of rice to multiple pathogens. Remarkably, overexpressing OsSRF3 enhances resistance without adversely affecting plant growth or yield. We show that BRASSINOSTEROID RECEPTOR-ASSOCIATED KINASE 1 (OsBAK1) interacts with and phosphorylates OsSRF3 to activate pathogen-triggered immunity, inducing the mitogen-activated protein kinase cascade, a reactive oxygen species burst, callose deposition, and expression of defense-related genes. UgsL interferes with the phosphorylation of OsSRF3 by OsBAK1. Furthermore, UgsL mediates OsSRF3 degradation by facilitating its association with the ubiquitin-26S proteasome. Our results reveal that OsSRF3 positively regulates immunity in rice and that UgsL mediates its degradation, thereby inhibiting the activation of OsBAK1-OsSRF3-mediated immune pathways.
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