Evidence map›Paper›PMID 39256385›Full record

ArticleNature communications2024

A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner.

Yanbo Kou, Shenghan Zhang, Junru Chen, Yusi Shen, Zhiwei Zhang, Haohan Huang, Yulu Ma, Yaoyao Xiang, Longxiang Liao, Junyang Zhou and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Safety ofViruses · 2026
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yanbo Kou *Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.ORCID 0000-0002-8794-4711
Shenghan Zhang *Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Junru ChenJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yusi ShenJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Zhiwei ZhangJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Haohan HuangJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yulu MaJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yaoyao XiangJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Longxiang LiaoJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Junyang ZhouJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Wanpeng ChengJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yuan ZhouXuzhou Key Laboratory of Laboratory Diagnostics, Medical Technology School, Xuzhou Medical University, Xuzhou, China.
Huan YangXuzhou Key Laboratory of Laboratory Diagnostics, Medical Technology School, Xuzhou Medical University, Xuzhou, China.
Zhuanzhuan LiuJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yanxia WeiJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Hui WangJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.
Yugang WangJiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China. wangyg@xzhmu.edu.cn.ORCID 0000-0002-0709-1924

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81700774National Natural Science Foundation of China (National Science Foundation of China) 81770853Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20231172
6 · The paper itself

Abstract

IgA antibodies play an important role in mucosal immunity. However, there is still no effective way to consistently boost mucosal IgA responses, and the factors influencing these responses are not fully understood. We observed that colonization with the murine intestinal symbiotic protozoan Tritrichomonas musculis (T.mu) boosted antigen-specific mucosal IgA responses in wild-type C57BL/6 mice. This enhancement was attributed to the accumulation of free arachidonic acid (ARA) in the intestinal lumen, which served as a signal to stimulate the production of antigen-specific mucosal IgA. When ARA was prevented from undergoing its downstream metabolic transformation using the 5-lipoxygenase inhibitor zileuton or by blocking its downstream biological signaling through genetic deletion of the Leukotriene B

Indexed as

Immunity, MucosalImmunoglobulin ALipid MetabolismMice, Inbred C57BLReceptors, Leukotriene B4Signal TransductionAnimalsArachidonic AcidFemaleGastrointestinal MicrobiomeIntestinal MucosaMiceMice, KnockoutArachidonic AcidImmunoglobulin ALtb4r1 protein, mouseReceptors, Leukotriene B4

Identifiers

PMID39256385
PMCPMC11387640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.