ArticleNature communications2024
Concept and location neurons in the human brain provide the 'what' and 'where' in memory formation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Mental Scene and Memory Construction and the Hippocampus.Hippocampus · 2026Article
- Human neuron activity during an 83-minute movie from 2,286 neurons and 29 patients.Scientific data · 2026Article
- Concept Cells and the Neural Bases of Human Memory.Acta physiologica (Oxford, England) · 2026Review
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Association of hippocampus, entorhinal cortex, and amygdala with thyroid function: a bilateral volumetric analysis.Thyroid research · 2026Article
- Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.bioRxiv : the preprint server for biology · 2025Article
- Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- fMRI signals of pattern separation in the neocortex and hippocampus to non-meaningful objects and their spatial location.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Our brains create new memories by capturing the 'who/what', 'where' and 'when' of everyday experiences. On a neuronal level, mechanisms facilitating a successful transfer into episodic memory are still unclear. We investigated this by measuring single neuron activity in the human medial temporal lobe during encoding of item-location associations. While previous research has found predictive effects in population activity in human MTL structures, we could attribute such effects to two specialized sub-groups of neurons: concept cells in the hippocampus, amygdala and entorhinal cortex (EC), and a second group of parahippocampal location-selective neurons. In both item- and location-selective populations, firing rates were significantly higher during successfully encoded trials. These findings are in line with theories of hippocampal indexing, since selective index neurons may act as pointers to neocortical representations. Overall, activation of distinct populations of neurons could directly support the connection of the 'what' and 'where' of episodic memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.