ArticleNature communications2024
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Dynamic DNA Nanomachines for Biosensing and Drug Delivery.Sensors (Basel, Switzerland) · 2026Review
- DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Spring-loaded DNA origami arrays as energy-supplied hardware for modular nanorobots.Science robotics · 2025Article
- Modulating transformation of DNA origami nanoarray via sequence design.Nature communications · 2025Article
- Single-Molecule Detection of Optical Signals Using DNA-Based Plasmonic Nanostructures.Biosensors · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Allostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems. We use a DNA origami domino array structure which-upon binding of trigger DNA strands-undergoes a stepwise allosteric conformational change. Using two FRET probes placed at specific positions in the DNA origami, we zoom in into single steps of this reaction cascade. Most of the steps are strongly coupled temporally and occur simultaneously. Introduction of activation energy barriers between different intermediate states alters this coupling and induces a time delay. We then apply these approaches to release a cargo DNA strand at a predefined step in the reaction cascade to demonstrate the applicability of this concept in tunable cascades of mechanochemical coupling with both spatial and temporal control.
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Registered trials
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