Evidence map›Paper›PMID 39256305›Full record

ArticleInflammation2025

Comparative Analysis of Canonical Inflammasome Activation by Flow Cytometry, Imaging Flow Cytometry and High-Content Imaging.

Nico Wittmann, Sander Bekeschus, Doreen Biedenweg, Daniela Kuthning, Christopher Pohl, Jana Gramenz, Oliver Otto, Lukas Bossaller, Almut Meyer-Bahlburg

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nico WittmannPediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, 17475, Greifswald, Germany.ORCID http://orcid.org/0000-0003-1301-3540
Sander BekeschusZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Straße 2, 17489, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8773-8862
Doreen BiedenwegInstitute for Physics, University of Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-4175-2618
Daniela KuthningPediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, 17475, Greifswald, Germany.ORCID http://orcid.org/0009-0009-3872-389X
Christopher PohlDepartment of General Surgery, Visceral, Thoracic and Vascular Surgery, University Medical Center Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-1182-1018
Jana GramenzPediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, 17475, Greifswald, Germany.
Oliver OttoInstitute for Physics, University of Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-0280-5374
Lukas BossallerSection of Rheumatology, Department of Medicine A, University Medicine, University of Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-0789-4062
Almut Meyer-BahlburgPediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, 17475, Greifswald, Germany. almut.meyer-bahlburg@med.uni-greifswald.de.ORCID http://orcid.org/0000-0001-8640-8282

Funding

European Regional Development Fund GHS-20-0031German Federal Ministry of Education and Research 03Z22CN11German Federal Ministry of Education and Research 03Z22DN11German Research Foundation Grant DFG BO 4325/3-1German Research Foundation Grant DFG ME 2709/5-1
6 · The paper itself

Abstract

Inflammasome activation occurs in various diseases, including rare diseases that require multicenter studies for investigation. Flow cytometric analysis of ASC speck

Indexed as

Flow CytometryInflammasomesLeukocytes, MononuclearCARD Signaling Adaptor ProteinsHumansMicroscopy, FluorescenceCARD Signaling Adaptor ProteinsInflammasomesPYCARD protein, humanASC (apoptosis-associated speck-like protein containing a caspase-recruitment domain)Flow cytometryMonocytesPeripheral blood mononuclear cellSpeck

Identifiers

PMID39256305
PMCPMC12234628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.