Evidence map›Paper›PMID 39256266›Full record

ArticleAlcohol, clinical & experimental research2024

Psychosocial predictors of return to alcohol use after liver transplant: A multicenter cohort study.

Kelly Torosian, Bita Shahrvini, Willie Mohammed Johnson, Irine Vodkin, Monica Tincopa, Nicholas Lim, Allison Kwong, Veeral Ajmera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Gender disparity in access to early liver transplant among patients with alcohol associated liver disease and limited sobriety is mediated by psychosocial factors.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kelly TorosianDivision of Gastroenterology and Hepatology, University of California, San Diego, San Diego, California, USA.
Bita ShahrviniDepartment of Medicine, University of California, San Diego, San Diego, California, USA.
Willie Mohammed JohnsonDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Irine VodkinDivision of Gastroenterology and Hepatology, University of California, San Diego, San Diego, California, USA.
Monica TincopaDivision of Gastroenterology and Hepatology, University of California, San Diego, San Diego, California, USA.
Nicholas LimDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.
Allison KwongDivision of Gastroenterology and Hepatology, Stanford University, Redwood City, California, USA.
Veeral AjmeraDivision of Gastroenterology and Hepatology, University of California, San Diego, San Diego, California, USA.ORCID https://orcid.org/0000-0001-5626-0942

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
A Novel Multimodal Approach to Characterize NAFLD Severity and PrognosisK23DK119460 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AJMERA, VEERAL HARESH · 2019 to 2023
$1.1M
Defining Phenotypes of Alcohol-Associated Liver Disease with Acute Hepatic DecompensationK23AA029197 · NIAAA · STANFORD UNIVERSITY · PI KWONG, ALLISON · 2021 to 2025
$1.0M
ACTRI Voucher Funding UL1TR001442NCATS NIH HHS UL1 TR001442NIAAA NIH HHS K23 AA-029197NIAAA NIH HHS K23 AA029197NIDDK NIH HHS K23 DK119460NIDDK NIH HHS K23DK119460NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

backgroundAlcohol use after liver transplant (LT) is associated with higher rates of graft loss and increased mortality; however, there are limited data evaluating predictors of return to alcohol use using biochemical markers like phosphatidylethanol (PEth).

methodsThis multicenter retrospective cohort study evaluated psychosocial predictors of return to alcohol use using PEth testing in patients transplanted for alcohol-associated liver disease (ALD). The study included 223 patients at three centers who had received a LT for ALD and had at least one PEth measurement post-LT.

resultsThe rate of return to alcohol use was 6.9 cases per 100 person-years (26 patients total) over a median 555 days of follow-up after transplant. Younger age (HR 0.96; 95% CI 0.92-0.99, p = 0.02), mental health comorbidities (HR 2.83; 95% CI 1.25-6.39, p = 0.01), and non-Hispanic White race (HR 3.79; 95% CI 1.42-10.15, p = 0.01) were associated with return to alcohol use post-LT. There was no difference between post-LT return to alcohol use rates or short-term survival among patients with less than 6 months of sobriety prior to listing compared with those with more than 6 months. Patients with sustained alcohol use post-LT had increased odds of history of illicit substance use (OR 5.20; 95% CI 1.01-26.83, p = 0.04) but no significant difference in time from the last drink to listing (OR 1.03; 95% CI 0.18-5.80, p = 0.97).

conclusionsThese findings emphasize the importance of mental health comorbidities rather than period of sobriety in predicting post-LT return to alcohol use. Furthermore, the higher risk of return to alcohol use in non-Hispanic White patients suggests a potential disparity with referral and selection of higher risk White patients.

Indexed as

alcohol‐associated liver diseasealcohol use disorderphosphatidylethanolsocial determinants of health

Identifiers

PMID39256266
PMCPMC11560536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.