Evidence map›Paper›PMID 39256245›Full record

ArticleSkeletal radiology2025

Clinical, imaging and pathological features of extraskeletal myxoid chondrosarcoma.

Amine El Kandoussi, Yin P Hung, Eric L Tung, Fabian Bauer, Joao R T Vicentini, Santiago Lozano-Calderon, Connie Y Chang

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Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amine El KandoussiDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA, 02114, USA.
Yin P HungDepartment of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Eric L TungDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA, 02114, USA.
Fabian BauerDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA, 02114, USA.
Joao R T VicentiniDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA, 02114, USA.
Santiago Lozano-CalderonDepartment of Orthopedic Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Connie Y ChangDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA, 02114, USA. cychang@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-1304-1576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate clinical and radiological features of extraskeletal myxoid chondrosarcomas (EMC). MATERIAL AND

methodsOur pathology database was queried for cases of EMCs. Tumor location, size, imaging appearance, presence of metastases, disease recurrence, and clinical outcome were documented. Imaging studies were evaluated in consensus by a musculoskeletal radiologist and an orthopedic oncologist.

resultsThirty subjects met the inclusion criteria (mean age 52.7 ± 16.2 years; 19 male, 11 female), 17 (56.7%) of which had pre-operative imaging. Tumors occurred most often in the lower extremities (20/30; 66.7%). All cases presented as a soft-tissue mass without mineralization on XR or CT. On MRI, tumors were typically hyperintense on T2-weighted sequences (14/14; 100%) and had a chondroid matrix appearance (12/14; 85.7%). Tumor invasion was observed in 11 out of 16 (68.9%) patients and necrosis in 2 out of 11 subjects (18.2%). All subjects had their tumors examined by pathology, and 20 (66.7%) subjects also had descriptive information in addition to the diagnosis (tumor invasion, mitotic rate, and necrosis) noted in the pathology reports. The mean duration of follow-up was 9.4 ± 7.5 (1.0 - 29.6) years. At the last follow-up, 14 out of 28 (50%) subjects were disease-free, 6 out of 28 had persistent metastatic disease and 8 out of 28 had died.

conclusionsEMC is a rare sarcoma that commonly presents as lower extremity soft tissue mass with chondroid appearance on MRI. Unlike conventional chondrosarcomas, EMC do not demonstrate mineralization on XR or CT.

Indexed as

ChondrosarcomaMagnetic Resonance ImagingNeoplasms, Connective and Soft TissueNeoplasms, Connective TissueTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesComputed tomographyExtraskeletal myxoid chondrosarcomaMagnetic resonance imagingPathology

Identifiers

PMID39256245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.