Evidence map›Paper›PMID 39256048›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice.

Tatiana V Lipina, Shupeng Li, Ekaterina S Petrova, Tamara G Amstislavskaya, Ryan T Cameron, Christina Elliott, Yoichi Gondo, Alexander McGirr, Jonathan G L Mullins, George S Baillie and 2 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Pde4 mediates MHCII expression in oligodendroglia.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatiana V LipinaDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada tatiana.lipina@utoronto.ca s.j.clapcote@leeds.ac.uk.
Shupeng LiSchool of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen 518071, China.
Ekaterina S PetrovaFederal State Budgetary Scientific Institution, Scientific Research Institute of Physiology & Basic Medicine, Novosibirsk 630117, Russia.
Tamara G AmstislavskayaFederal State Budgetary Scientific Institution, Scientific Research Institute of Physiology & Basic Medicine, Novosibirsk 630117, Russia.
Ryan T CameronSchool of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Christina ElliottSchool of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Yoichi GondoMutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.
Alexander McGirrHotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Jonathan G L MullinsInstitute of Life Science, Swansea University, Swansea SA3 5AU, United Kingdom.
George S BaillieSchool of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.ORCID 0000-0003-2469-6316
James R WoodgettLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Steven J ClapcoteSchool of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom tatiana.lipina@utoronto.ca s.j.clapcote@leeds.ac.uk.ORCID 0000-0002-6662-5690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large-scale genome-wide association studies (GWASs) have associated intronic variants in

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 4Mutation, MissenseStress Disorders, Post-TraumaticAnimalsFearGenetic Predisposition to DiseaseHEK293 CellsHumansMaleMiceMice, Inbred C57BLPhenotypeReflex, StartleCyclic Nucleotide Phosphodiesterases, Type 4PDE4B protein, mousecAMPfear memoryPDE4BPTSDschizophreniatrauma

Identifiers

PMID39256048
PMCPMC11502227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.