Evidence map›Paper›PMID 39256039›Full record

ArticleeNeuro2024

Presynaptic Enhancement of Transmission from Nociceptors Expressing Nav1.8 onto Lamina-I Spinothalamic Tract Neurons by Spared Nerve Injury in Mice.

Wei-Chen Hung 洪瑋辰, Chih-Cheng Chen 陳志成, Cheng-Tung Yen 嚴震東, Ming-Yuan Min 閔明源

Abstract read
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In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei-Chen Hung 洪瑋辰Department of Life Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Chih-Cheng Chen 陳志成Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Cheng-Tung Yen 嚴震東Department of Life Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Ming-Yuan Min 閔明源Department of Life Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.ORCID https://orcid.org/0000-0003-4211-6725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alteration of synaptic function in the dorsal horn (DH) has been implicated as a cellular substrate for the development of neuropathic pain, but certain details remain unclear. In particular, the lack of information on the types of synapses that undergo functional changes hinders the understanding of disease pathogenesis from a synaptic plasticity perspective. Here, we addressed this issue by using optogenetic and retrograde tracing ex vivo to selectively stimulate first-order nociceptors expressing Nav1.8 (NRs

Indexed as

Excitatory Postsynaptic PotentialsNAV1.8 Voltage-Gated Sodium ChannelNociceptorsSpinothalamic TractsSynaptic TransmissionAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicOptogeneticsNAV1.8 Voltage-Gated Sodium ChannelScn10a protein, mousebrain sliceschronic painoptogeneticsspinal cordsynaptic plasticity

Identifiers

PMID39256039
PMCPMC11391502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.