Evidence map›Paper›PMID 39256032›Full record

ArticleGut2025

AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense

Máté Sándor, Isabelle Scheers, Atsushi Masamune, Heiko Witt, Jessica LaRusch, Jian-Min Chen, Balázs Csaba Németh, Andrea Geisz, Aliye Uc, Miklós Sahin-Tóth

Abstract readLetter
In one paragraph

Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. MisfoldingAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  3. Article
  4. Zoological research · 2025
    Article
  5. Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Máté SándorDepartment of Surgery, University of California Los Angeles, Los Angeles, California, USA.
Isabelle ScheersDepartment of Pediatric Gastroenterology and Hepatology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Heiko WittPaediatric Nutritional Medicine, Else Kröner-Fresenius Zentrum für Ernährungsmedizin (EKFZ), Technische Universität München (TUM), Freising, Germany.
Jessica LaRuschAriel Precision Medicine, Pittsburgh, Pennsylvania, USA.
Jian-Min ChenUniv Brest, Inserm, EFS, UMR 1078, GGB, F-29200, Brest, France.ORCID http://orcid.org/0000-0002-2424-3969
Balázs Csaba NémethCenter for Gastroenterology, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Andrea GeiszDepartment of Surgery, Boston University, Boston, Massachusetts, USA.
Aliye UcStead Family Department of Pediatrics and Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA.ORCID http://orcid.org/0000-0003-2004-5743
Miklós Sahin-TóthDepartment of Surgery, University of California Los Angeles, Los Angeles, California, USA msahintoth@mednet.ucla.edu.ORCID http://orcid.org/0000-0003-4513-9922

Funding

Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Chymotrypsin in pancreatitisR01DK082412 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2009 to 2024
$5.8M
A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic PancreatitisR01DK118752 · NIDDK · UNIVERSITY OF IOWA · PI PALERMO, TONYA M, UC, ALIYE · 2018 to 2022
$3.0M
Trypsin-dependent mechanisms in pancreatitisR01DK117809 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2018 to 2022
$2.5M
NIDDK NIH HHS R01 DK082412NIDDK NIH HHS R01 DK117809NIDDK NIH HHS R01 DK118752NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CHRONIC PANCREATITISGENETIC TESTINGPANCREATIC DISORDERS

Identifiers

PMID39256032
PMCPMC11885027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.