Evidence map›Paper›PMID 39255977›Full record

ArticleGenome research2024

Evidence for compensatory evolution within pleiotropic regulatory elements.

Zane Kliesmete, Peter Orchard, Victor Yan Kin Lee, Johanna Geuder, Simon M Krauß, Mari Ohnuki, Jessica Jocher, Beate Vieth, Wolfgang Enard, Ines Hellmann

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zane KliesmeteAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0001-7017-6616
Peter OrchardAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0001-6097-1106
Victor Yan Kin LeeAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0009-0001-5598-9632
Johanna GeuderAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0002-5070-3404
Simon M KraußAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0009-0009-8514-5500
Mari OhnukiAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0001-5478-6297
Jessica JocherAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0002-1615-5993
Beate ViethAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0002-8415-1695
Wolfgang EnardAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany.ORCID 0000-0002-4056-0550
Ines HellmannAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, 82152 Munich, Germany; hellmann@bio.lmu.de.ORCID 0000-0003-0588-1313

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of

Indexed as

Evolution, MolecularGenetic PleiotropyRegulatory Sequences, Nucleic AcidAnimalsConserved SequenceHumansMacacaTranscription FactorsTranscription Factors

Identifiers

PMID39255977
PMCPMC11534155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.