Evidence map›Paper›PMID 39255799›Full record

ArticleCell metabolism2024

m

Ling Xiao, Dario F De Jesus, Cheng-Wei Ju, Jiang Bo Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, Cheryl Cero, Ville Männistö, Suvi M Manninen and 8 more

Abstract read
In one paragraph

Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Role of NMedComm · 2026
    Review
  5. mInternational journal of molecular medicine · 2026
    Review
  6. Review
  7. NBiomolecules · 2026
    Review
  8. Review
  9. mAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  10. Article
  11. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Divergent roles of mNature communications · 2025
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

  • Update of
    m2023
5 · Who and what money

Authors and funding

18 authors.

Ling XiaoSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Dario F De JesusSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Cheng-Wei JuDepartment of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.
Jiang Bo WeiDepartment of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.
Jiang HuSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Ava DiStefano-FortiSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Tadataka TsujiSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
Cheryl CeroDiabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Ville MännistöDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Suvi M ManninenInstitute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Siying WeiSection of Islet Cell and Regenerative Biology, and CRISPR Screen Core Laboratory, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Medical School, Boston, MA, USA.
Oluwaseun IjaduolaSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Aaron M CypessDiabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Jussi PihlajamäkiInstitute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland; Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland.
Yu-Hua TsengSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
Chuan HeDepartment of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.
Rohit N KulkarniSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, BIDMC, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA. Electronic address: rohit.kulkarni@joslin.harvard.edu.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Role of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0M
Epitranscriptomics in human obesity and type 2 diabetesRC2DK139552 · NIDDK · JOSLIN DIABETES CENTER · PI Mengjie Chen, CHUAN HE · 2024 to 2026
$6.0M
Interrogation of dynamic RNA modifications in beta cells in type 1 diabetesUC4DK116278 · NIDDK · JOSLIN DIABETES CENTER · PI HE, CHUAN, KULKARNI, ROHIT N. · 2017 to 2017
$1.9M
Develop new bioinformatics infrastructures and computational tools for epitranscriptomics dataR01HG012927 · NHGRI · UNIVERSITY OF CHICAGO · PI Mengjie Chen · 2023 to 2026
$1.6M
Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetesR00DK135927 · NIDDK · UNIVERSITY OF CHICAGO · PI Dario F De Jesus · 2025 to 2026
$498k
Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetesK99DK135927 · NIDDK · JOSLIN DIABETES CENTER · PI F DE JESUS, DARIO · 2023 to 2024
$180k
American Heart Association-American Stroke Association 903968NHGRI NIH HHS R01 HG012927NHGRI NIH HHS RM1 HG008935NIDDK NIH HHS K99 DK135927NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R00 DK135927NIDDK NIH HHS R01 DK067536NIDDK NIH HHS RC2 DK139552NIDDK NIH HHS UC4 DK116278NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Brown adipose tissue (BAT) regulates systemic metabolism by releasing signaling lipids. N

Indexed as

AdenosineAdipose Tissue, BrownInsulin ResistanceRNA, MessengerSignal TransductionUncoupling Protein 1AnimalsDiet, High-FatDinoprostoneHumansMaleMethylationMethyltransferasesMiceMice, Inbred C57BLMice, KnockoutAdenosineDinoprostoneMethyltransferasesN-methyladenosineProstaglandinsRNA, MessengerUncoupling Protein 1brown fathumaninsulin sensitivityinter-organ communicationm(6)AMETTL14prostaglandins

Identifiers

PMID39255799
PMCPMC11891809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.