Evidence map›Paper›PMID 39255798›Full record

ReviewAmerican journal of human genetics2024

The methodological and ethical concerns of genetic studies of same-sex sexual behavior.

Christa Ventresca, Daphne O Martschenko, Robbee Wedow, Mete Civelek, James Tabery, Jedidiah Carlson, Stephen C J Parker, Paula S Ramos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of human genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Science and sensitivity in the study of not having sex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Confounding fuels misinterpretation in human genetics.Proceedings. Biological sciences · 2025
    Article
  7. Review
  8. Confounding Fuels Misinterpretation in Human Genetics.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christa VentrescaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48103, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48103, USA. Electronic address: christav@umich.edu.
Daphne O MartschenkoCenter for Biomedical Ethics, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Robbee WedowDepartment of Sociology, Purdue University, West Lafayette, IN 47907, USA; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; AnalytiXIN, Indianapolis, IN 46259, USA; Center on Aging and the Life Course, Purdue University, West Lafayette, IN 47907, USA; Department of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Mete CivelekDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22904, USA.
James TaberyDepartment of Philosophy, University of Utah, Salt Lake City, UT 84112, USA.
Jedidiah CarlsonDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA.
Stephen C J ParkerDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48103, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48103, USA; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48103, USA.
Paula S RamosDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Resource CoreP30AR072582 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JAMES C OATES · 2017 to 2026
$8.5M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
A Multi-stakeholder Approach to the ELSI of Social and Behavioral Genomics: Investigating the Field's Downstream Implications to Mitigate Harms, Promote Benefits, and Locate Social ResponsibilityK01HG013352 · NHGRI · STANFORD UNIVERSITY · PI Daphne Oluwaseun Martschenko · 2024 to 2026
$886k
NHGRI NIH HHS K01 HG013352NIAMS NIH HHS P30 AR072582NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32 GM149391
6 · The paper itself

Abstract

Same-sex sexual behavior has long interested genetics researchers in part because, while there is evidence of heritability, the trait as typically defined is associated with fewer offspring. Investigations of this phenomenon began in the 1990s with linkage studies and continue today with the advent of genome-wide association studies. As this body of research grows, so does critical scientific and ethical review of it. Here, we provide a targeted overview of existing genetics studies on same-sex sexual behavior, highlight the ethical and scientific considerations of this nascent field, and provide recommendations developed by the authors to enhance social and ethical responsibility.

Indexed as

Genome-Wide Association StudySexual BehaviorFemaleHomosexualityHumansMale

Identifiers

PMID39255798
PMCPMC11480801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.