Evidence map›Paper›PMID 39255274›Full record

ArticlePLoS computational biology2024

The primacy model and the structure of olfactory space.

Hamza Giaffar, Sergey Shuvaev, Dmitry Rinberg, Alexei A Koulakov

Abstract read
In one paragraph

Article in PLoS computational biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Order code in the olfactory system.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamza GiaffarCold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.
Sergey ShuvaevCold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.
Dmitry RinbergNeuroscience Institute, New York University Langone Health, New York, New York, United States of America.
Alexei A KoulakovCold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.ORCID 0009-0002-1570-9293

Funding

The Structure of Olfactory Neural and Perceptual SpacesU19NS112953 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RINBERG, DMITRY · 2019 to 2023
$18.4M
NINDS NIH HHS U19 NS112953
6 · The paper itself

Abstract

Understanding sensory processing involves relating the stimulus space, its neural representation, and perceptual quality. In olfaction, the difficulty in establishing these links lies partly in the complexity of the underlying odor input space and perceptual responses. Based on the recently proposed primacy model for concentration invariant odor identity representation and a few assumptions, we have developed a theoretical framework for mapping the odor input space to the response properties of olfactory receptors. We analyze a geometrical structure containing odor representations in a multidimensional space of receptor affinities and describe its low-dimensional implementation, the primacy hull. We propose the implications of the primacy hull for the structure of feedforward connectivity in early olfactory networks. We test the predictions of our theory by comparing the existing receptor-ligand affinity and connectivity data obtained in the fruit fly olfactory system. We find that the Kenyon cells of the insect mushroom body integrate inputs from the high-affinity (primacy) sets of olfactory receptors in agreement with the primacy theory.

Indexed as

OdorantsOlfactory Receptor NeuronsReceptors, OdorantSmellAnimalsComputational BiologyDrosophilaModels, NeurologicalMushroom BodiesOlfactory PathwaysReceptors, Odorant

Identifiers

PMID39255274
PMCPMC11423968

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.