Evidence map›Paper›PMID 39255003›Full record

ArticleeLife2024

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.

Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic and 4 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Nonapoptotic role of EGL-1 in exopher production and neuronal health inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Extracellular vesicles.Genetics · 2024
    Review
  7. Non-apoptotic role of EGL-1 in exopher production and neuronal health inbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Guoqiang Wang *Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.ORCID https://orcid.org/0000-0002-3694-7103
Ryan J Guasp *Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Sangeena Salam *Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Edward ChuangDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Andrés MoreraDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Anna J SmartDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
David JimenezDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Sahana ShekharDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Emily FriedmanDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Ilija MelentijevicDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.
Ken C NguyenDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, United States.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, United States.
Barth D GrantDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.ORCID https://orcid.org/0000-0002-5943-8336
Monica DriscollDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, United States.ORCID https://orcid.org/0000-0002-8751-7429

Funding

IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Defining Roles of Genetics and Age in Extrusion of Neurotoxic AggregatesR37AG056510 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2017 to 2026
$5.3M
Understanding the Exopher: A Novel Mechanism for Extrusion of Neurotoxic ContentsR01AG047101 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI DRISCOLL, MONICA A., GRANT, BARTH DEMIAN · 2013 to 2022
$4.2M
Molecular regulation of endosome fission during endocytic recyclingR01GM135326 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Barth Demian Grant · 2020 to 2026
$2.6M
NIA NIH HHS R01 AG047101NIA NIH HHS R01AG047101NIA NIH HHS R37 AG056510NIA NIH HHS R37AG56510NIGMS NIH HHS 5R01GM135326NIGMS NIH HHS K12 GM093854NIGMS NIH HHS K12GM093854NIGMS NIH HHS R01 GM135326NIH HHS P40 OD010440NIH HHS R24 OD010943NIH Office of the Director R24OD010943
6 · The paper itself

Abstract

Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as exophers produced by proteostressed

Indexed as

Caenorhabditis elegansNeuronsAnimalsCaenorhabditis elegans ProteinsFemaleMaleUterusCaenorhabditis elegans ProteinsC. elegansexopherextracellular vesiclemechanical stressmechanobiologyneuroscienceproteostasistransgenerational signaling

Identifiers

PMID39255003
PMCPMC11386954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.