The food-borne carcinogenic 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) disrupts circadian rhythms and ameliorated by pterostilbene (PSB) in Caenorhabditis elegans.

Chun-Han Chang, Pei-Ling Yen, Min-Hsiung Pan, Vivian Hsiu-Chuan Liao

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Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Chun-Han ChangInstitute of Food Science and Technology, National Taiwan University, Taipei, 106, Taiwan.

Pei-Ling YenDepartment of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, 106, Taiwan.

Min-Hsiung PanInstitute of Food Science and Technology, National Taiwan University, Taipei, 106, Taiwan. mhpan@ntu.edu.tw.

Vivian Hsiu-Chuan LiaoDepartment of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, 106, Taiwan. vivianliao@ntu.edu.tw.ORCID 0000-0002-4676-9953

Funding

National Science and Technology Council MOST 111-2320-B-002-030-MY3National Science and Technology Council MOST 111-2811-B-002-134NTU Core Consortiums NTU-CC-113L894702

6 · The paper itself

Abstract

The food-borne 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a potential human carcinogen abundant in cooked meat. While circadian rhythms are crucial biological oscillations, the negative impact of PhIP on circadian systems and the potential of mitigation remain underexplored. We investigated the effects of PhIP on circadian rhythms and the mitigating effects of the phytochemical antioxidant pterostilbene (PSB) in Caenorhabditis elegans. We show that exposure to 10 μM PhIP disrupts the 24-h circadian rhythms of C. elegans, an effect mitigated by co-exposure to 100 μM PSB. In addition, PhIP-induced circadian disruption can be linked to defective oxidative stress resistance, which is associated with the DAF-16/FOXO pathway and is modulated by PSB. Molecular docking suggested that PhIP and PSB bind similarly to DAF-16. Moreover, 10 μM PhIP abolished the rhythmic expression of the core clock gene prdx-2, which is restored by 100 μM PSB. Findings from this study provide novel insight of how food-borne contaminant like PhIP may contribute to the disruption of circadian rhythms and suggest potential for PSB to mitigate these effects in higher organisms.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsCarcinogensCircadian RhythmImidazolesOxidative StressStilbenesAnimalsAntioxidantsForkhead Transcription FactorsMolecular Docking Simulation2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridineAntioxidantsCaenorhabditis elegans ProteinsCarcinogensdaf-16 protein, C elegansForkhead Transcription FactorsImidazolespterostilbeneStilbenesC. elegansCircadian rhythmFood-bornePhIPPterostilbene

Identifiers

PMID39254834

DOI10.1073/pnas.0701599104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.