Evidence map›Paper›PMID 39254699›Full record

ArticleJournal of neurology2024

Takotsubo syndrome in a Sardinian amyotrophic lateral sclerosis cohort.

A Maccabeo, M I Pateri, F Pili, S Pilotto, V Pierri, A Muroni, T Ercoli, R Montisci, M F Marchetti, A Martis and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Prevalence and impact of comorbidities in amyotrophic lateral sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

A MaccabeoDepartment of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy. alessandramaccabeo@outlook.it.ORCID http://orcid.org/0009-0005-7779-5897
M I PateriDepartment of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy.
F PiliNeurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
S PilottoDepartment of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy.
V PierriDepartment of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy.
A MuroniNeurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
T ErcoliDepartment of Neurology, University of Sassari, Viale S. Pietro 10, 07100, Sassari, Italy.
R MontisciCardiology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
M F MarchettiCardiology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
A MartisDepartment of Medical Sciences and Public Health, Institute of Cardiology, University of Cagliari, Cagliari, Italy.
L FazziniDepartment of Medical Sciences and Public Health, Institute of Cardiology, University of Cagliari, Cagliari, Italy.
G DefazioDepartment of Translational Biomedicine and Neurosciences, University of Bari "Aldo Moro", Bari, Italy.
M PulighedduNeurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
G BorgheroNeurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAmyotrophic lateral sclerosis (ALS) is known to be associated with varying degrees of autonomic and cardiovascular dysfunction. Recent case reports showed that ALS may be linked to Takotsubo syndrome (TTS). We assessed the frequency of TTS in an incident ALS cohort from Sardinia, Italy, and investigated the relationship of TTS with ALS course.

methodsWe retrospectively examined a 10-year (2010-2019) incident cohort of ALS patients of Sardinian ancestry, reported TTS frequency and patients' clinical characteristics. Following, we checked for TTS among patients with ALS onset after 2019 and focused on the same features as for the incident cohort.

resultsOur incident cohort included 344 ALS patients and 5 of them (1.45%) developed TTS. All were female and their median onset age was 71.5 years (IQR 62.75-77). Two patients had spinal and three bulbar onset, though all patients had bulbar involvement and were at an advanced stage of disease (ALSFRS ≤ 25, King's ≥ 3) at TTS diagnosis. We identified a potential TTS trigger in three patients (hospitalization for PEG placement, pneumonia). Among patients who had ALS onset after 2019, we identified a further TTS case and described it.

conclusionTTS is not a rare condition in ALS. Female sex, bulbar involvement, and later age of disease onset may be important risk factors for developing this cardiac condition and a physical or psychological trigger is often observed. Despite autonomic dysfunction in ALS has been already demonstrated, the precise physiopathological mechanism underlying TTS needs to be further clarified.

Indexed as

Amyotrophic Lateral SclerosisTakotsubo CardiomyopathyAgedCohort StudiesFemaleHumansItalyMaleMiddle AgedRetrospective StudiesALSAutonomic dysfunctionBulbarTakotsubo cardiomyopathy

Identifiers

PMID39254699
PMCPMC11588819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.