Evidence map›Paper›PMID 39254446›Full record

ArticleRadiology2024

Combining Radiomics and Autoencoders to Distinguish Benign and Malignant Breast Tumors on US Images.

Zuzanna Anna Magnuska, Rijo Roy, Moritz Palmowski, Matthias Kohlen, Brigitte Sophia Winkler, Tatjana Pfeil, Peter Boor, Volkmar Schulz, Katja Krauss, Elmar Stickeler and 1 more

Abstract read
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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Zuzanna Anna MagnuskaFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).ORCID 0000-0001-5732-715X
Rijo RoyFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).ORCID 0000-0002-7669-3179
Moritz PalmowskiFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Matthias KohlenFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Brigitte Sophia WinklerFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Tatjana PfeilFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Peter BoorFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Volkmar SchulzFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Katja KraussFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Elmar StickelerFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).
Fabian KiesslingFrom the Institute for Experimental Molecular Imaging (Z.A.M., R.R., M.P., V.S., F.K.), Institute of Pathology (P.B.), and Department of Obstetrics and Gynecology (M.K., B.S.W., T.P., K.K., E.S.), University Clinic Aachen, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany; Physics Institute III B, RWTH Aachen University, Aachen, Germany (V.S.); Comprehensive Diagnostic Center Aachen, Uniklinik RWTH Aachen, Aachen, Germany (P.B., V.S., E.S., F.K.); and Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (P.B., V.S., F.K.).ORCID 0000-0002-7341-0399

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background US is clinically established for breast imaging, but its diagnostic performance depends on operator experience. Computer-assisted (real-time) image analysis may help in overcoming this limitation. Purpose To develop precise real-time-capable US-based breast tumor categorization by combining classic radiomics and autoencoder-based features from automatically localized lesions. Materials and Methods A total of 1619 B-mode US images of breast tumors were retrospectively analyzed between April 2018 and January 2024. nnU-Net was trained for lesion segmentation. Features were extracted from tumor segments, bounding boxes, and whole images using either classic radiomics, autoencoder, or both. Feature selection was performed to generate radiomics signatures, which were used to train machine learning algorithms for tumor categorization. Models were evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity and were statistically compared with histopathologically or follow-up-confirmed diagnosis. Results The model was developed on 1191 (mean age, 61 years ± 14 [SD]) female patients and externally validated on 50 (mean age, 55 years ± 15]). The development data set was divided into two parts: testing and training lesion segmentation (419 and 179 examinations) and lesion categorization (503 and 90 examinations). nnU-Net demonstrated precision and reproducibility in lesion segmentation in test set of data set 1 (median Dice score [DS]: 0.90 [IQR, 0.84-0.93];

Indexed as

Breast NeoplasmsUltrasonography, MammaryAdultAgedBreastDiagnosis, DifferentialFemaleHumansImage Interpretation, Computer-AssistedMachine LearningMiddle AgedRadiomicsRetrospective StudiesSensitivity and Specificity

Identifiers

PMID39254446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.