Evidence map›Paper›PMID 39254327›Full record

ArticleApplied and environmental microbiology2024

Engineering probiotic

Mengdie Fang, Ruiting Zhang, Chenyu Wang, Zhizhi Liu, Mingyue Fei, Biao Tang, Hua Yang, Dongchang Sun

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengdie Fang *College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.ORCID 0009-0002-2961-1967
Ruiting Zhang *College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.
Chenyu WangCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.
Zhizhi LiuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.
Mingyue FeiCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.
Biao TangState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China.ORCID 0000-0002-3605-4022
Hua YangState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China.
Dongchang SunCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.ORCID 0000-0003-0405-4623

Funding

Foundation of Zhejiang Academy of Medical Sciences YS2022005Key Research and Development Program of Zhejiang Province (Key R&D plan of Zhejiang Province) 2020C02031MOST | National Natural Science Foundation of China (NSFC) 32170083,31670084MOST | NSFC | NSFC-Zhejiang Joint Fund | | Basic Public Welfare Research Program of Zhejiang Province () LHDMY23H160003Open Foundation of State Key Laboratary Cultivation Base of Hazard Factors and Risk Control of Quanlity and Safety of Agticultural Products 2021DG700024-KF202105
6 · The paper itself

Abstract

Many multidrug-resistant (MDR) bacteria have evolved through the accumulation of antibiotic resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of ARGs has been recognized, strategies for blocking the transfer of ARGs while using probiotics have rarely been explored. The probiotic IMPORTANCE: To reduce the development of antibiotic resistance, probiotics have been considered as a substitute for antibiotics. However, probiotics themselves are reservoirs of antibiotic resistance genes (ARGs). This study introduces a new strategy for limiting the spread of ARGs by engineering the typical probiotic strain

Indexed as

Anti-Bacterial AgentsCRISPR-Cas SystemsEscherichia coliProbioticsAnimalsDrug Resistance, Multiple, BacterialGenetic EngineeringZebrafishAnti-Bacterial Agentsantibiotic resistance geneconjugationCRISPR-CasEscherichia coli Nissle 1917probiotics

Identifiers

PMID39254327
PMCPMC11497782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.