Evidence map›Paper›PMID 39254295›Full record

ArticleAntimicrobial agents and chemotherapy2024

Evolution toward extremely high imipenem resistance in

Eva Le Run, Hervé Tettelin, Steven M Holland, Adrian M Zelazny

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genetic analysis ofiScience · 2026
    Article
  3. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Eva Le RunLaboratory of Clinical Immunology and Microbiology (LCIM), Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.ORCID 0009-0003-6744-5848
Hervé TettelinDepartment of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Steven M HollandLaboratory of Clinical Immunology and Microbiology (LCIM), Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
Adrian M ZelaznyDepartment of Laboratory Medicine (DLM), Microbiology Service, Clinical Center, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-2847-7428

Funding

HHS | National Institutes of Health (NIH) Intramural Research
6 · The paper itself

Abstract

Treatment of

Indexed as

Anti-Bacterial Agentsbeta-LactamasesImipenemMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase InhibitorsCystic FibrosisDisease OutbreaksDrug Resistance, BacterialHumansAnti-Bacterial AgentsavibactamAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-LactamasesImipenemantimicrobial resistancebeta-lactamNTM

Identifiers

PMID39254295
PMCPMC11459939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.