Evidence map›Paper›PMID 39254234›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Gender differences in the association between education and late-life cognitive function in the LifeAfter90 Study: A multiethnic cohort of the oldest-old.

Jennifer O Lam, Rachel A Whitmer, Maria M Corrada, Claudia H Kawas, Katherine E Vieira, Charles P Quesenberry, Paola Gilsanz

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer O LamDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Rachel A WhitmerDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Maria M CorradaDepartment of Neurology, University of California Irvine, Orange, California, USA.
Claudia H KawasDepartment of Neurology, University of California Irvine, Orange, California, USA.
Katherine E VieiraDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany Nicole Dugger · 2021 to 2026
$25.2M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Electronic Health Record-Based Dementia Prediction for HIV Primary CareK01AI157849 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAM, JENNIFER · 2021 to 2025
$713k
MPIs: Whitmer, Corrada, Gilsanz R01AG056519NIAID NIH HHS K01 AI157849NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG056519NIA NIH HHS R01 AG066132PI: Gilsanz The Judy Fund/2019-AARGD-644788PI: Lam K01AI157849
6 · The paper itself

Abstract

introductionFew studies have examined the relationship between education and cognition among the oldest-old.

methodsCognitive assessments were conducted biannually for 803 participants (62.6% women) of LifeAfter90, a longitudinal study of individuals ≥ 90 years old. Gender differences in associations between education (< high school, high school, some college, and ≥ college) and cognition (verbal episodic memory, semantic memory, and executive function) were examined at baseline and longitudinally using linear mixed models.

resultsHigher education levels were associated with better cognitive performance at baseline for both men and women. College completion was more strongly associated with better baseline executive function among women. Education-cognition associations for baseline verbal episodic memory and baseline semantic memory did not differ by gender. Education was not associated with a decline in any domain-specific cognitive scores, regardless of gender. DISCUSSION: Education is associated with cognitive function among the oldest-old and varies by gender and cognitive domain at baseline but not over time. HIGHLIGHTS: In the oldest-old, higher education was associated with better cognitive function. College completion was more strongly associated with executive function in women. Education was not associated with cognitive decline after age 90 regardless of gender. Improving education could decrease gaps in cognitive level among older individuals.

Indexed as

CognitionEducational StatusExecutive FunctionNeuropsychological TestsAged, 80 and overFemaleHumansLongitudinal StudiesMaleSex Factorsagingcognitioncognitive functiondisparityeducationgender

Identifiers

PMID39254234
PMCPMC12060128

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.