Evidence map›Paper›PMID 39254221›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Factors associated with cognitive reserve according to education level.

Yeshin Kim, Yaakov Stern, Sang Won Seo, Duk L Na, Jae-Won Jang, Hyemin Jang, Cognitive Reserve Research Group of Korea Dementia Association

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. [Progress on prognostic assessment methods for mild cognitive impairment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  8. Cognition and psychomotor vigilance in treated sleep apnea patients with and without daytime sleepiness: the MAGNETO study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
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  15. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yeshin KimDepartment of Neurology, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.ORCID 0000-0002-4643-5478
Yaakov SternCognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Sang Won SeoDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Duk L NaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Jae-Won JangDepartment of Neurology, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.
Hyemin JangDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Cognitive Reserve Research Group of Korea Dementia Association

Funding

Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government (MSIT) 2022-0-00159Kangwon National University Hospital 2023Korea Dementia Research Project through the Korea Dementia Research Center (KDRC), funded by the Ministry of Health & Welfare and Ministry of Science and ICT RS-2020-KH107436Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center (KDRC), funded by the Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea HU20C0414Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare and Ministry of science and ICT RS-2022-KH125667Korea National Institute of Health research project 2024-ER1001-00National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) NRF-2020R1A2C1009778National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) RS-2023-00212076
6 · The paper itself

Abstract

introductionWe investigated distinctive factors associated with cognitive reserve (CR) based on education level.

methodsAmong 1247 participants who underwent neuropsychological assessment, amyloid positron emission tomography, and brain magnetic resonance imaging, 336 participants with low education (≤6 years) and 697 with high education (≥12 years) were selected. CR was measured as the difference between the predicted and observed value of cognitive function based on cortical thickness. Multiple linear regression was conducted in each group after controlling for age and sex.

resultsIn the low-education group, low literacy, long sleep duration(>8 h/day), and diabetes were negatively associated with CR, whereas cognitive and physical activity were positively associated with CR. In the high-education group, cognitive activity was positively related to CR, whereas low literacy, long sleep duration (> 8 h/day), and depression were negatively related to CR. DISCUSSION: This study provides insights into different strategies for enhancing CR based on educational background. HIGHLIGHTS: Factors associated with cognitive reserve (CR) varied according to the education level. Diabetes and physical activity were associated with CR in the low-education group. Depression was related to CR in the high-education group. Low literacy, sleep duration, and cognitive activity were associated with CR in both groups. Dementia-prevention strategies should be tailored according to educational level.

Indexed as

Cognitive ReserveEducational StatusMagnetic Resonance ImagingNeuropsychological TestsPositron-Emission TomographyAgedBrainExerciseFemaleHumansMaleMiddle AgedAlzheimer's diseasecognitive reserveeducationrisk factors

Identifiers

PMID39254221
PMCPMC11567866

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.