Evidence map›Paper›PMID 39254214›Full record

ReviewLiver international : official journal of the International Association for the Study of the Liver2025

Role of liver biopsy in the management of idiosyncratic DILI.

David E Kleiner

Abstract readReview
In one paragraph

Review in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Navigating liver toxicity in the age of novel oncological agents.JHEP reports : innovation in hepatology · 2025
    Review
  5. Histopathological Changes as a Predictor of Fatal Outcome in Patients With Drug-Induced Liver Injury.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  6. Review
  7. Role of liver biopsy in the management of idiosyncratic DILI.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David E KleinerChief Post-Mortem Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0003-3442-4453

Funding

Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
CCR NIH HHS ZIC BC 010685Intramural NIH HHS ZIC BC010685
6 · The paper itself

Abstract

Drug-induced liver injury (DILI) presents unique challenges in clinical practice. While some types of DILI are mild and resolve quickly after removing the drug, other situations are more complex, with competing aetiologies or underlying liver disease. Guidelines from professional societies agree that the liver biopsy retains a role in understanding and managing DILI in certain situations. Liver biopsy allows characterization of the histological pattern of injury as well as assessment of severity. Inflammatory infiltrates, bile duct injury or loss and vascular injury are all revealed by liver biopsy. Communication between the hepatopathologist and clinical team with clinicopathological correlation of the findings is necessary for the best determination of causality and differentiation from other diseases of exclusion, like autoimmune hepatitis and graft-versus-host disease. This review highlights important aspects of the role of liver biopsy in DILI evaluation.

Indexed as

Chemical and Drug Induced Liver InjuryLiverBiopsyHepatitis, AutoimmuneHumansSeverity of Illness Indexautoimmune hepatitiscausalitydifferential diagnosisgraft‐versus‐host diseasehepatotoxicity

Identifiers

PMID39254214
PMCPMC11815619

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.