ArticleHuman brain mapping2024
Compressed cerebro-cerebellar functional gradients in children and adolescents with attention-deficit/hyperactivity disorder.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Physical exercise as a non-pharmacological strategy for ADHD considering neurobiological mechanisms, cognitive benefits, and practical recommendations: a narrative review.European archives of psychiatry and clinical neuroscience · 2026Review
- Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks.JAMA psychiatry · 2026Article
- Transformer-based structural connectivity networks for ADHD-related connectivity alterations.Communications medicine · 2025Article
- Mapping ADHD Heterogeneity and Biotypes through Topological Deviations in Morphometric Similarity Networks.medRxiv : the preprint server for health sciences · 2025Article
- The etiology of attention deficit disorder with hyperactivity: A protocol for an umbrella review.PloS one · 2025Article
- Compressed cerebro-cerebellar functional gradients in children and adolescents with attention-deficit/hyperactivity disorder.Human brain mapping · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Both cortical and cerebellar developmental differences have been implicated in attention-deficit/hyperactivity disorder (ADHD). Recently accumulating neuroimaging studies have highlighted hierarchies as a fundamental principle of brain organization, suggesting the importance of assessing hierarchy abnormalities in ADHD. A novel gradient-based resting-state functional connectivity analysis was applied to investigate the cerebro-cerebellar disturbed hierarchy in children and adolescents with ADHD. We found that the interaction of functional gradient between diagnosis and age was concentrated in default mode network (DMN) and visual network (VN). At the same time, we also found that the opposite gradient changes of DMN and VN caused the compression of the cortical main gradient in ADHD patients, implicating the co-occurrence of both low- (visual processing) and high-order (self-related thought) cognitive dysfunction manifesting in abnormal cerebro-cerebellar organizational hierarchy in ADHD. Our study provides a neurobiological framework to better understand the co-occurrence and interaction of both low-level and high-level functional abnormalities in the cortex and cerebellum in ADHD.
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