Evidence map›Paper›PMID 39254112›Full record

ArticleAnalytical chemistry2024

Yizhe Zhang, Isao Naguro, Hiroki Ryuno, Amy E Herr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Single-Cell Protein Assays in Context: From 2D to 3D and In Situ Analysis.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

4 authors.

Yizhe ZhangDepartment of Bioengineering, University of California-Berkeley, Berkeley, California 94720, United States.ORCID 0000-0003-2624-3329
Isao NaguroGraduate School of Pharmaceutical Sciences The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Hiroki RyunoGraduate School of Pharmaceutical Sciences The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Amy E HerrDepartment of Bioengineering, University of California-Berkeley, Berkeley, California 94720, United States.ORCID 0000-0002-6906-2985

Funding

MULTIPLEXED ISOFORM QUANTIFICATION IN HER2-POSITIVE BREAST CANCERR01CA203018 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HERR, AMY ELIZABETH · 2016 to 2024
$2.8M
Advanced Cancer Classification via Single-Cell Electrophoretic CytopathologyR33CA225296 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HERR, AMY ELIZABETH · 2017 to 2017
$1.5M
NCI NIH HHS R01 CA203018NCI NIH HHS R33 CA225296
6 · The paper itself

Abstract

Extracellular signal-regulated kinase (ERK) signaling is essential to regulated cell behaviors, including cell proliferation, differentiation, and apoptosis. The influence of cell-cell contacts on ERK signaling is central to epithelial cells, yet few studies have sought to understand the same in cancer cells, particularly with single-cell resolution. To acquire same-cell measurements of both phenotypic (cell-contact state) and targeted-protein (ERK phosphorylation) profiles, we prepend high-content, whole-cell imaging prior to end-point cellular-resolution Western blot analyses for each of hundreds of individual HeLa cancer cells cultured on that same chip, which we call

Identifiers

PMID39254112
PMCPMC11447967

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.