Evidence map›Paper›PMID 39254088›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Activation of platelets and the complement system in mice with

Claudia Mickael, Mariah Jordan, Janelle N Posey, Rubin M Tuder, Eva S Nozik, Joshua M Thurman, Kurt R Stenmark, Brian B Graham, Cassidy A Delaney

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. A Novel Role for Platelet-Endothelial Crosstalk in Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudia MickaelDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-1064-311X
Mariah JordanSection of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Janelle N PoseySection of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-2846-9260
Rubin M TuderDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Eva S NozikSection of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-7229-5528
Joshua M ThurmanDivision of Renal Disease and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-9062-3559
Kurt R StenmarkDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-6918-6411
Brian B GrahamDepartment of Medicine, University of California, San Francisco, California, United States.ORCID 0000-0001-7541-2585
Cassidy A DelaneySection of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0003-2861-9377

Funding

Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI TUDER, RUBIN M. · 2020 to 2024
$14.1M
The Complement System and Ischemic Acute Renal FailureR01DK076690 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Joshua M Thurman · 2008 to 2026
$6.6M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseasesR35HL139726 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NOZIK, EVA S. · 2018 to 2024
$4.1M
PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseasesR25HL146166 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Matthew Wayne DeCamp, Sonia Castro Flores · 2019 to 2026
$3.4M
Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary HypertensionK01HL161024 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Claudia Silva Mickael · 2022 to 2026
$661k
American Thoracic Society (ATS) Early Career InvestigatorEntelligence Entelligence Young Investigator AwardHHS | National Institutes of Health (NIH) R01DK076690HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R35HL139726HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL161024HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL152961HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL135872HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R25HL146166NHLBI NIH HHS K01 HL161024NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL135872NHLBI NIH HHS R25 HL146166NHLBI NIH HHS R35 HL139726NIAID NIH HHS HHSN272201700014CNIDDK NIH HHS R01 DK076690
6 · The paper itself

Abstract

Schistosomiasis-induced pulmonary hypertension (PH) presents a significant global health burden, yet the underlying mechanisms remain poorly understood. Here, we investigate the involvement of platelets and the complement system in the initiation events leading to

Indexed as

Blood PlateletsHypertension, PulmonaryPlatelet ActivationAnimalsComplement ActivationComplement C3aComplement C5aComplement System ProteinsFemaleLungMaleMiceMice, Inbred C57BLSchistosomaSchistosomiasisComplement C3aComplement C5aComplement System Proteinscomplementinflammationplateletpulmonary hypertensionSchistosoma

Identifiers

PMID39254088
PMCPMC11563640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.