Evidence map›Paper›PMID 39254086›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Magnitude of obesity alone does not alter the alveolar lipidome.

William G Tharp, Carolyn R Morris, Yulica Santos-Ortega, Calvin P Vary, S Patrick Bender, Anne E Dixon

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. The bronchoalveolar proteome changes in obesity.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  4. Article
  5. Pulmonary iron oxide (FeHuman & experimental toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William G TharpDepartment of Anesthesiology, University of Vermont, Burlington, Vermont, United States.ORCID 0000-0003-4642-8750
Carolyn R MorrisDepartment of Medicine, University of Vermont, Burlington, Vermont, United States.ORCID 0000-0002-5200-7859
Yulica Santos-OrtegaCenter for Molecular Medicine, MaineHealth Institute for Research, Scarborough, Maine, United States.
Calvin P VaryCenter for Molecular Medicine, MaineHealth Institute for Research, Scarborough, Maine, United States.
S Patrick BenderDepartment of Anesthesiology, University of Vermont, Burlington, Vermont, United States.
Anne E DixonDepartment of Medicine, University of Vermont, Burlington, Vermont, United States.

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$25.1M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) L30HL149005-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM121301HHS | NIH | National Institute of General Medical Sciences (NIGMS) U54GM115516International Anesthesia Research Society (IARS)NIGMS NIH HHS P20 GM121301
6 · The paper itself

Abstract

Obesity may lead to pulmonary dysfunction through complex and incompletely understood cellular and biochemical effects. Altered lung lipid metabolism has been identified as a potential mechanism of lung dysfunction in obesity. Although murine models of obesity demonstrate changes in pulmonary surfactant phospholipid composition and function, data in humans are lacking. We measured untargeted shotgun lipidomes in two bronchoalveolar lavages (BALs) from apical and anteromedial pulmonary subsegments of 14 adult subjects (7 males and 7 females) with body mass indexes (BMIs) ranging from 24.3 to 50.9 kg/m

Indexed as

Bronchoalveolar Lavage FluidLipidomicsObesityPulmonary AlveoliAdultBody Mass IndexFemaleHumansLipid MetabolismMaleMiddle AgedPhospholipidsPulmonary SurfactantsPhospholipidsPulmonary Surfactantsbronchoalveolar lavagelipidomelungobesitysurfactant

Identifiers

PMID39254086
PMCPMC11563641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.