Evidence map›Paper›PMID 39254055›Full record

ArticleNMR in biomedicine2024

The impact of isoflurane anesthesia on brain metabolism in mice: An MRI and electroencephalography study.

Zhiliang Wei, Seung-Eon Roh, Xiuli Yang, Wenshen Wang, Jiekang Wang, Lin Chen, Yuguo Li, Adnan Bibic, Hanzhang Lu

Abstract read
In one paragraph

Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Metabolic Differences in Neuroimaging with [Tomography (Ann Arbor, Mich.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiliang WeiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Seung-Eon RohDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xiuli YangDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wenshen WangRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiekang WangDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lin ChenF. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
Yuguo LiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Adnan BibicF. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
Hanzhang LuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel diseaseR01AG081932 · NIA · JOHNS HOPKINS UNIVERSITY · PI Zhiliang Wei · 2023 to 2026
$2.1M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsR01AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2024 to 2026
$1.6M
Characterization and validation of cerebrovascular reactivity (CVR) as a biomarker of vascular dementia in mouse modelsR21NS119960 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WEI, ZHILIANG · 2021 to 2021
$465k
Brain & Behavior Research Foundation AG064792Brain & Behavior Research Foundation AG066507Brain & Behavior Research Foundation AG071515Brain & Behavior Research Foundation AG081932Brain & Behavior Research Foundation EB031771Brain & Behavior Research Foundation NS119960Brain & Behavior Research Foundation P30Brain & Behavior Research Foundation P41Brain & Behavior Research Foundation R01Brain & Behavior Research Foundation R21NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG064792NIA NIH HHS R01 AG071515NIA NIH HHS R01 AG081932NIBIB NIH HHS P41 EB031771NIH HHSNINDS NIH HHS R21 NS119960
6 · The paper itself

Abstract

Isoflurane is one of the most widely used anesthetic agents in rodent imaging studies. However, the impact of isoflurane on brain metabolism has not been fully characterized to date, primarily due to a scarcity of noninvasive technologies to quantitatively measure the brain's metabolic rate in vivo. In this study, using noncontrast MRI techniques, we dynamically measured cerebral metabolic rate of oxygen (CMRO

Indexed as

BrainElectroencephalographyIsofluraneMagnetic Resonance ImagingAnesthesiaAnesthetics, InhalationAnimalsMaleMiceMice, Inbred C57BLOxygenAnesthetics, InhalationIsofluraneOxygencerebral blood flowcerebral metabolic rate of oxygenelectroencephalogramisofluranemouseoxygen extraction fraction

Identifiers

PMID39254055
PMCPMC11563868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.