Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Qian Shi *Department of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0003-2634-9553
Jinxi WangDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0002-7349-6153
Hamza MalikDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0009-0008-2758-9835
Xuguang LiDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0002-0187-6616
Jennifer StreeterDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0002-6965-9546
Jacob SharafuddinDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0009-0003-1024-7568
Eric WeatherfordDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0002-4890-2359
David SteinThe Charles Bronfman Institute for Personalized Medicine (D.S., Y.I.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-5131-8313
Yuval ItanThe Charles Bronfman Institute for Personalized Medicine (D.S., Y.I.), Icahn School of Medicine at Mount Sinai, New York, NY.
Biyi ChenDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0003-0402-7537
Duane HallDepartment of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0003-2228-0966
Long-Sheng Song *Department of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0002-6035-8106
E Dale Abel *Department of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.ORCID 0000-0001-5290-0738
Funding
Novel Functions of the E-C Coupling Structural Protein Junctophilin-2 in the HeartR01HL130346 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2016 to 2023
$4.4M
ERK1/2-Integrin Signaling in Desmosome-Dyad CrosstalkR01HL157741 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.5M
Insulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4M
Molecular Determinants of MG53 in Heart Structure and FunctionR01HL157781 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.2M
Cardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6M
Insulin Resistance and Myocardial AutophagyR01HL108379 · NHLBI · UNIVERSITY OF UTAH · PI ABEL, E DALE · 2011 to 2014
backgroundThe docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of
methodsA retrospective analysis of an electronic medical record database was conducted to identify patients with
resultsThe retrospective analysis identified patients with
conclusionsCardiac IRS2 inhibits sympathetic stress-induced AKT/NOS3/CaMKII/RyR2 overactivation and calcium-dependent arrhythmogenesis. This novel IRS2 signaling axis, essential for maintaining cardiac calcium homeostasis under stress, presents a promising target for developing new antiarrhythmic therapies.
Indexed as
Arrhythmias, CardiacCalciumHomeostasisInsulin Receptor Substrate ProteinsMice, KnockoutMyocytes, CardiacRyanodine Receptor Calcium Release ChannelAdultAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingFemaleHumansMaleMiceMiddle AgedCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Insulin Receptor Substrate ProteinsIRS2 protein, humanIrs2 protein, mouseProto-Oncogene Proteins c-aktryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelRyR2 protein, humanarrhythmias, cardiaccalciumcalcium-calmodulin-dependent protein kinase type 2insulin receptor substrate proteinsryanodine receptor calcium release channel
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca · full record | OpenQuestion