Evidence map›Paper›PMID 39253775›Full record

ArticleJournal of cosmetic dermatology2024

Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation.

Dongmei Wu, Pingping Lv, Ping Han, Lingna Xie, Yi Li, Congwei Ma, Meiling Tai, Yi Peng, Li Lin

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongmei WuThe School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.ORCID https://orcid.org/0009-0007-6016-3775
Pingping LvInfinitus Company Ltd., R&D Center, Guangzhou, China.
Ping HanFoshan Conney Allan Biotechnology Co. Ltd, Foshan, China.
Lingna XieThe School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.
Yi LiThe School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.
Congwei MaThe School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.
Meiling TaiInfinitus Company Ltd., R&D Center, Guangzhou, China.
Yi PengState Key Laboratory Basis of Xinjiang indigenous medicinal plants resource utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Li LinFoshan Conney Allan Biotechnology Co. Ltd, Foshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSolar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In this study, we evaluated the efficacy and underlying mechanism of TCMM, a combination of TCM and monomers in repairing solar lentigo.

methodsWe detected and identified the main compounds of TCM using liquid chromatography-mass spectrometry (LC-MS) and through the approach of network pharmacology, we screened drug and disease targets, visualized networks with Cytoscape software, analyzed targets via Gene ontology and KEGG, clinically validated predictions. In a mouse model, UVB-induced pigmentation was assessed, and the effects of TCMM were evaluated. A clinical trial on 30 patients validated the depigmenting agent.

resultsActive ingredients such as MSH, Butylated hydroxytoluen, Valerophenone, and Geranylacetone aid pigmentation treatment. One hundred and forty-three crore targets impact PI3K-Akt, MAPK signaling pathway, ect. pathways. TCMM reduced UVB-induced pigmentation, water loss, epidermal thickness, and melanin. It inhibited TYR, MITF, AKT1, VEGFA, PTGS2, TNF-α, IL-6, IL-1β. Clinical and microscopic analysis showed significant pigmentation reduction.

conclusionsThe treatment of solar lentigo can benefit from the TCMM. By targeting multiple factors and pathways, this approach offers a comprehensive and effective treatment strategy.

Indexed as

Drugs, Chinese HerbalLentigoMedicine, Chinese TraditionalNetwork PharmacologyAdultAnimalsDisease Models, AnimalFemaleHumansMaleMiceMiddle AgedSkin Lightening PreparationsSkin PigmentationTreatment OutcomeUltraviolet RaysDrugs, Chinese HerbalSkin Lightening Preparationsclinical validationLC–MSnetwork pharmacologyskin solar lentigotraditional Chinese medicines and monomers(TCMM)

Identifiers

PMID39253775
PMCPMC11626378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.