Evidence map›Paper›PMID 39253730›Full record

ArticlePhysics and imaging in radiation oncology2024

Feasibility of simulation free abdominal stereotactic adaptive radiotherapy using an expedited pre-plan workflow.

Alex T Price, Joshua P Schiff, Alice Silberstein, Robbie Beckert, Tianyu Zhao, Geoffrey D Hugo, Pamela P Samson, Eric Laugeman, Lauren E Henke

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Adaptive radiotherapy for gastrointestinal malignancies.Radiation oncology (London, England) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alex T PriceUniversity Hospitals Seidman Cancer Center, Department of Radiation Oncology, Cleveland, OH, USA.
Joshua P SchiffWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Alice SilbersteinWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Robbie BeckertWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Tianyu ZhaoWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Geoffrey D HugoWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Pamela P SamsonWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Eric LaugemanWashington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
Lauren E HenkeUniversity Hospitals Seidman Cancer Center, Department of Radiation Oncology, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Improved hounsfield-unit accuracy of on-board imaging may lead to direct-to-unit treatment approaches We aimed to demonstrate the feasibility of using only a diagnostic (dx) computed tomography (CT)-defined target pre-plan in an Materials and Methods: Eight patients with abdominal treatment sites (five pancreatic cancer, three oligometastases) were treated using an integrated adaptive O-Ring gantry system. Each patient's target was delineated on a dxCT. The target only pre-plan served primarily to seed the ART process. During the ART session, all structures were delineated. All simulated cases were treated to 50 Gy in 5 fractions to a planning target optimization structure (PTV_OPT) to allow for dose escalation within the planning target volume. Timing of steps during this workflow was recorded. Plan quality was compared between ART treatment plans and a plan created on a CT simulation scan using the traditional planning workflow. Results: The workflow was feasible in all attempts, with organ-at-risk (OAR) constraints met in all fractions despite lack of initial OAR contours. Median absolute difference between the adapted plan and simulation CT plan for the PTV_Opt V95% was 2.0 %. Median absolute difference in the D0.5 cm Conclusion: The workflow was feasible for a dxCT-defined target-only pre-plan approach to stereotactic abdominal ART.

Indexed as

Adaptive radiotherapyPancreasSBRTSimulation-free

Identifiers

PMID39253730
PMCPMC11382001

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.