ArticleDEN open2025
Recurrence rates and risk factors in obscure gastrointestinal bleeding.
Article in DEN open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Risk Stratification for Rebleeding in Obscure Gastrointestinal Bleeding After Comprehensive Gastrointestinal Evaluation.DEN open · 2027Article
- Diagnostic Efficacy and Clinical Aspects of Panoramic-View Versus Forward-View Capsule Endoscopy for Suspected Small Bowel Bleeding: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- The predictive value of platelet-to-lymphocyte ratio and lymphocyte count in recurrent small intestinal hemorrhage: a retrospective cohort study.BMC gastroenterology · 2026Article
- Heyde Syndrome Complicated by Alcoholic Liver Cirrhosis in Which Aortic Valve Stenosis Was Diagnosed due to Gastrointestinal Bleeding.Internal medicine (Tokyo, Japan) · 2025Article
- Diverticular bleeding in the third part of the duodenum as a cause of overt obscure gastrointestinal bleeding.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obscure gastrointestinal bleeding (OGIB), defined in 2010, involves bleeding from the GI tract that remains unexplained after standard diagnostic procedures. OGIB, which accounts for about 5% of all GI bleeds, poses diagnostic and management challenges, particularly due to the anatomical features of the small intestine. Advances in capsule endoscopy (CE) and balloon-assisted endoscopy have improved the diagnostic and therapeutic landscape for small intestinal lesions. Objective: To determine the recurrence rate and identify risk factors for recurrence following diagnostic and therapeutic interventions using CE and balloon-assisted endoscopy in patients with OGIB. Methods: A retrospective cohort study at Gifu University Hospital analyzed CE procedures for patients with OGIB from 2008 to 2022. Patients underwent CE with subsequent treatments based on the findings. Statistical analyses, including Kaplan-Meier and Cox proportional hazards models, were used to estimate cumulative recurrence rates and identify recurrence risk factors. Results: Out of 417 patients, 65.2% had positive CE findings, leading to therapeutic interventions in 16.3% of cases. The cumulative recurrence rates at 12, 24, and 36 months were 4.3%, 9.0%, and 13.9%, respectively. Liver cirrhosis (hazard rate: 4.15, 95% confidence interval 1.88-9.18, Conclusions: A significant recurrence rate in OGIB patients, with liver cirrhosis being a major risk factor. Despite diagnostic and therapeutic advances, a comprehensive approach including careful follow-up and consideration of risk factors is essential for management.
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