Evidence map›Paper›PMID 39253614›Full record

ReviewFrontiers in aging neuroscience2024

Advancements in strategies for overcoming the blood-brain barrier to deliver brain-targeted drugs.

Zhichuang Qu, Juan Luo, Zheng Li, Rong Yang, Jiaxi Zhao, Xin Chen, Sixun Yu, Haifeng Shu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. [Mechanisms and intervention strategies by which neuropsychological stress promotes central nervous system tumor recurrence through bloodZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhichuang Qu *Department of Neurosurgery, Meishan City People's Hospital, Meishan, China.
Juan Luo *Department of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Zheng LiDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Rong YangDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Jiaxi ZhaoDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Xin ChenDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Sixun YuDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
Haifeng ShuDepartment of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier is known to consist of a variety of cells and complex inter-cellular junctions that protect the vulnerable brain from neurotoxic compounds; however, it also complicates the pharmacological treatment of central nervous system disorders as most drugs are unable to penetrate the blood-brain barrier on the basis of their own structural properties. This dramatically diminished the therapeutic effect of the drug and compromised its biosafety. In response, a number of drugs are often delivered to brain lesions in invasive ways that bypass the obstruction of the blood-brain barrier, such as subdural administration, intrathecal administration, and convection-enhanced delivery. Nevertheless, these intrusive strategies introduce the risk of brain injury, limiting their clinical application. In recent years, the intensive development of nanomaterials science and the interdisciplinary convergence of medical engineering have brought light to the penetration of the blood-brain barrier for brain-targeted drugs. In this paper, we extensively discuss the limitations of the blood-brain barrier on drug delivery and non-invasive brain-targeted strategies such as nanomedicine and blood-brain barrier disruption. In the meantime, we analyze their strengths and limitations and provide outlooks on the further development of brain-targeted drug delivery systems.

Indexed as

blood–brain barrierbrain-targeted drugscell transportnanomaterialsphysical stimulation

Identifiers

PMID39253614
PMCPMC11381257

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.