Evidence map›Paper›PMID 39253520›Full record

ArticlebioRxiv : the preprint server for biology2024

Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors.

Sasikumar Kotagiri, Yawen Wang, Yanyan Han, Xiaobing Liang, Nicholas Blazanin, Phuong Kieu Nguyen, Yongying Jiang, Yonathan Lissanu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sasikumar Kotagiri
Yawen Wang
Yanyan Han
Xiaobing Liang
Nicholas Blazanin
Phuong Kieu Nguyen
Yongying Jiang

Funding

Mechanisms and Vulnerabilities of SWI/SNF chromatin remodeling complex mutant lung cancerR37CA251629 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LISSANU, YONATHAN · 2020 to 2025
$3.3M
Targeting SMARCA2 as a therapeutic strategy in SMARCA4 mutant lung cancerR01CA272945 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yonathan Lissanu · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA272945NCI NIH HHS R37 CA251629
6 · The paper itself

Abstract

Cancer genomic studies have identified frequent mutations in subunits of the SWI/SNF chromatin remodeling complex including

Identifiers

PMID39253520
PMCPMC11383272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.