Evidence map›Paper›PMID 39253519›Full record

ArticlebioRxiv : the preprint server for biology2024

Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit.

Cheng Lyu, Zhuoran Li, Chuanyun Xu, Kenneth Kin Lam Wong, David J Luginbuhl, Colleen N McLaughlin, Qijing Xie, Tongchao Li, Hongjie Li, Liqun Luo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Cheng LyuDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-2921-3061
Zhuoran LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Chuanyun XuDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Kenneth Kin Lam WongDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
David J LuginbuhlDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Colleen N McLaughlinDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Qijing XieDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Tongchao LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Hongjie LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Liqun LuoDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
NIDCD NIH HHS R01 DC005982
6 · The paper itself

Abstract

The distribution of postsynaptic partners in three-dimensional (3D) space presents complex choices for a navigating axon. Here, we discovered a dimensionality reduction principle in establishing the 3D glomerular map in the fly antennal lobe. Olfactory receptor neuron (ORN) axons first contact partner projection neuron (PN) dendrites at the 2D spherical surface of the antennal lobe during development, regardless of whether the adult glomeruli are at the surface or interior of the antennal lobe. Along the antennal lobe surface, axons of each ORN type take a specific 1D arc-shaped trajectory that precisely intersects with their partner PN dendrites. Altering axon trajectories compromises synaptic partner matching. Thus, a 3D search problem is reduced to 1D, which simplifies synaptic partner matching and may generalize to the wiring process of more complex brains.

Identifiers

PMID39253519
PMCPMC11383009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.