Evidence map›Paper›PMID 39253511›Full record

ArticlebioRxiv : the preprint server for biology2024

Epididymis-specific RNase A family genes regulate fertility and small RNA processing.

Joshua F Shaffer, Alka Gupta, Geetika Kharkwal, Edgardo E Linares, Andrew D Holmes, Sol Katzman, Upasna Sharma

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Joshua F ShafferDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.
Alka GuptaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.
Geetika KharkwalDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.
Edgardo E LinaresDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.
Andrew D HolmesDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.
Sol KatzmanGenomics Institute, University of California, Santa Cruz, California, 95064.
Upasna SharmaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064.

Funding

Paternal contributions to offspring health: Intergenerational epigenetic inheritance via sperm small RNAsDP2AG066622 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SHARMA, UPASNA · 2019 to 2019
$2.3M
LTQ XL Linear Quadrupole Ion Trap Mass SpectrometerS10RR025622 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI KOHLSTAEDT, LORI · 2009 to 2009
$463k
NCRR NIH HHS S10 RR025622NIA NIH HHS DP2 AG066622
6 · The paper itself

Abstract

Sperm small RNAs are implicated in intergenerational transmission of paternal environmental effects. Small RNAs generated by cleavage of tRNAs, known as tRNA fragments (tRFs), are an abundant class of RNAs in mature sperm, and can be modulated by environmental conditions. The ribonuclease(s) responsible for the biogenesis of tRFs in the male reproductive tract remains unknown. Angiogenin, a member of the Ribonuclease A superfamily (RNase A), cleaves tRNAs to generate tRFs in response to cellular stress. Four paralogs of Angiogenin, namely

Identifiers

PMID39253511
PMCPMC11383283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.