Evidence map›Paper›PMID 39253509›Full record

ArticlebioRxiv : the preprint server for biology2024

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable

Sohyung Lee, Spencer Zhao, Weihua Jiang, Xinyang Chen, Lingyun Zhu, John Joseph, Eli Agus, Helna Baby Mary, Shumaim Barooj, Kai Slaughter and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sohyung LeeHarvard Medical School, Boston, MA, USA.
Spencer ZhaoCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Weihua JiangDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY 14215, USA.
Xinyang ChenCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Lingyun ZhuCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
John JosephHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-0232-6042
Eli AgusCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Helna Baby MaryCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Shumaim BaroojCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Kai SlaughterCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Krisco CheungCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
James N LuoHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-9782-2323
Chetan ShuklaCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jingjing GaoHarvard Medical School, Boston, MA, USA.
Dongtak LeeHarvard Medical School, Boston, MA, USA.
Biji BalakrishnanSomaiya Centre for Integrated Science education and research, SKSC, Somaiya Vidyavihar University, Mumbai, 400077, India.
Christopher JiangCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Amogh GorantlaCenter for Accelerated Medical Innovation, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sukyung WooDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY 14215, USA.
Jeffrey M KarpHarvard Medical School, Boston, MA, USA.
Nitin JoshiHarvard Medical School, Boston, MA, USA.

Funding

Surmounting substance use disorder using an ultra-long acting injectable platform.R21DA057701 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI JOSHI, NITIN, KARP, JEFFREY MICHAEL · 2023 to 2024
$471k
NIDA NIH HHS R21 DA057701
6 · The paper itself

Abstract

Achieving ultra-long-term release of hydrophilic drugs over several months remains a significant challenge for existing long-acting injectables (LAIs). Existing platforms, such as

Identifiers

PMID39253509
PMCPMC11382995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.