Evidence map›Paper›PMID 39253425›Full record

ArticlebioRxiv : the preprint server for biology2025

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions.

Lindsey F Snyder, Emily M O'Brien, Jia Zhao, Jinye Liang, Baylee J Bruce, Yuning Zhang, Wei Zhu, Thomas H Cassier, Nicholas J Schnicker, Xu Zhou and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lindsey F SnyderInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-5926-5239
Emily M O'BrienDepartment of Biology, University of Iowa, Iowa City, IA, USA.
Jia ZhaoDepartment of Biology, University of Iowa, Iowa City, IA, USA.
Jinye LiangDepartment of Biology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-4161-9307
Baylee J BruceInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-9914-5597
Yuning ZhangDepartment of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA.ORCID 0000-0002-2967-4207
Wei ZhuDepartment of Molecular Genetics & Microbiology, Duke University, Durham, NC, USA.
Thomas H CassierDepartment of Biology, University of Iowa, Iowa City, IA, USA.
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-5189-4943
Xu ZhouDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Raluca GordânDepartment of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA.ORCID 0000-0002-6404-6556
Bin Z HeInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-3072-6238

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1M
Evolution of Stress Response Gene Regulatory Network in a Commensal and Opportunistic Yeast PathogenR35GM137831 · NIGMS · UNIVERSITY OF IOWA · PI HE, BIN Z · 2020 to 2024
$1.9M
Understanding Immune-Stromal Interactions in Tissue Homeostasis and InflammationR35GM151000 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI XU ZHOU · 2023 to 2026
$1.8M
The role of transcription factor proteins in mutagenesis at regulatory sitesR01GM135658 · NIGMS · DUKE UNIVERSITY · PI GORDAN, RALUCA · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM135658NIGMS NIH HHS R35 GM137831NIGMS NIH HHS R35 GM151000NIGMS NIH HHS T32 GM008629
6 · The paper itself

Abstract

Combinatorial control by transcription factors (TFs) is central to eukaryotic gene regulation, yet its mechanism, evolution, and regulatory impact are not well understood. Here we use natural variation in the yeast phosphate starvation (PHO) response to examine the genetic basis and species variation in TF interdependence. In

Identifiers

PMID39253425
PMCPMC11383300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.