Evidence map›Paper›PMID 39253417›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses.

Young-Jun Park, Chen Liu, Jimin Lee, Jack T Brown, Chen-Bao Ma, Peng Liu, Qing Xiong, Cameron Stewart, Amin Addetia, Caroline J Craig and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Young-Jun ParkDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Chen LiuState Key Laboratory of Virology, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University; Wuhan, Hubei, 430072, China.
Jimin LeeDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Jack T BrownDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Chen-Bao MaState Key Laboratory of Virology, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University; Wuhan, Hubei, 430072, China.
Peng LiuState Key Laboratory of Virology, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University; Wuhan, Hubei, 430072, China.
Qing XiongState Key Laboratory of Virology, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University; Wuhan, Hubei, 430072, China.
Cameron StewartDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Amin AddetiaDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Caroline J CraigDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
M Alejandra TortoriciDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.
Abeer AlshukariCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Tyler StarrDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Huan YanState Key Laboratory of Virology, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University; Wuhan, Hubei, 430072, China.
David VeeslerDepartment of Biochemistry, University of Washington; Seattle, WA 98195, USA.

Funding

Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Structure-based design of broadly protective coronavirus vaccinesP01AI167966 · NIAID · UNIVERSITY OF WASHINGTON · PI Francois J Villinger · 2022 to 2026
$15.3M
Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeuticsDP1AI158186 · NIAID · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2020 to 2024
$5.4M
University of Utah Genetics Training ProgramT32GM141848 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GOLIC, KENT G, GRUNWALD, DAVID J. · 2021 to 2025
$2.9M
From genomics to natural language processing: A protected environment for research computing in the health scienceS10OD021644 · OD · UNIVERSITY OF UTAH · PI CHEATHAM, THOMAS E. · 2017 to 2017
$494k
NIAID NIH HHS 75N93022C00036NIAID NIH HHS DP1 AI158186NIAID NIH HHS P01 AI167966NIGMS NIH HHS T32 GM141848NIH HHS S10 OD021644
6 · The paper itself

Abstract

DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity with which merbecoviruses engage ACE2 and their receptor species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing

Identifiers

PMID39253417
PMCPMC11383307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.