Evidence map›Paper›PMID 39253381›Full record

ArticleFrontiers in pharmacology2024

The deuterated pyrazoloquinolinone targeting α6 subunit-containing GABA

Pi-Chuan Fan, Lih-Chu Chiou, Tzu-Hsuan Lai, Dishary Sharmin, James Cook, Ming Tatt Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pi-Chuan FanDepartment of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lih-Chu ChiouClinical Center for Neuroscience and Behavior, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Hsuan LaiDepartment of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Dishary SharminDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, United States.
James CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, United States.
Ming Tatt LeeDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Funding

Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

Introduction: The α6 subunit-containing GABA Methods: Here, we tested whether the deuterated analogues of Compound 6, namely DK-1-56-1 and RV-I-29, known to have longer half-lives than the parent compound, can exert a similar therapeutic effect in the same model. The activation of TGVS was triggered by intra-cisternal ( Results: DK-I-56-1 and RV-I-29, administered intraperitoneally ( Discussion: These results suggest that DK-I-56-1 is a promising candidate for novel migraine pharmacotherapy, through positively modulating TG α6GABA

Indexed as

GABApositive allosteric modulatorpyrazoloquinolinonetrigeminal gangliatrigeminovascular systemα6GABAAR

Identifiers

PMID39253381
PMCPMC11381949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.