Evidence map›Paper›PMID 39253356›Full record

ArticleMolecular therapy. Methods & clinical development2024

Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine.

Francesca Ferraresso, Katherine Badior, Monica Seadler, Youjie Zhang, Amanda Wietrzny, Massimo F Cau, Amber Haugen, Geoffrey G Rodriguez, Mitchell R Dyer, Pieter R Cullis and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Rational design of lipid nanoparticles for enabling gene therapies.Molecular therapy. Methods & clinical development · 2025
    Review
  11. Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles.Molecular therapy. Methods & clinical development · 2025
    Article
  12. Review
  13. Review
  14. Circular RNAs modulate cancer drug resistance: advances and challenges.Cancer drug resistance (Alhambra, Calif.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca FerraressoVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Katherine BadiorVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Monica SeadlerVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Youjie ZhangVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Amanda WietrznyVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Massimo F CauMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Amber HaugenVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Geoffrey G RodriguezVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Mitchell R DyerVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Pieter R CullisDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Eric JanDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Christian J KastrupVersiti Blood Research Institute, Milwaukee, WI 53226, USA.

Funding

Understanding and Controlling the Contribution of Fibrinolysis to Bleeding Using a Long-Acting Antifibrinolytic RNA TherapyR01HL166382 · NHLBI · VERSITI WISCONSIN, INC. · PI Christian Kastrup · 2023 to 2026
$2.9M
NHLBI NIH HHS R01 HL166382
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bone marrowbrainextrahepatic expressiongene therapylarge animal modellipid nanoparticlesmegakaryocytemRNAnanomedicineswine

Identifiers

PMID39253356
PMCPMC11382111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.