Evidence map›Paper›PMID 39253312›Full record

ArticleWorld journal of critical care medicine2024

Low T3

Mirza Kovacevic, Visnja Nesek-Adam, Semir Klokic, Ekrema Mujaric

Abstract read
In one paragraph

Article in World journal of critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mirza KovacevicDepartment of Anesthesiology, Resuscitation and Intensive Care, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina. kovacevic.mirza@hotmail.com.
Visnja Nesek-AdamDepartment of Anesthesiology, Resuscitation and Intensive Care, Clinical Hospital Sveti Duh, Zagreb 10000, Croatia.
Semir KlokicGruppenpraxis, General Practitioner's Office, Laufen 4242, Switzerland.
Ekrema MujaricDepartment of Internal Diseases, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth phases of euthyroid sick syndrome (ESS) are associated with worse prognosis in septic shock patients. Although there are still no indications for supplementation therapy, there is no evidence that both phases (initial and prolonged) are adaptive or that only prolonged is maladaptive and requires supplementation.

aimTo analyze clinical, hemodynamic and laboratory differences in two groups of septic shock patients with ESS.

methodsA total of 47 septic shock patients with ESS were divided according to values of their thyroid hormones into low T3 and low T3T4 groups. The analysis included demographic data, mortality scores, intensive care unit stay, mechanical ventilation length and 28-day survival and laboratory with hemodynamics.

resultsThe Simplified Acute Physiology Score II score (

conclusionThe low T3T4 population is associated with higher frequency of renal insufficiency and MOF, with worse laboratory and hemodynamic parameters. These findings suggest potentially maladaptive changes in the chronic phase of septic shock.

Indexed as

Euthyroid sick syndromeIntensive care unitLow T3Low T3T4Septic shock

Identifiers

PMID39253312
PMCPMC11372517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.