Evidence map›Paper›PMID 39253107›Full record

ArticleThe journal of allergy and clinical immunology. Global2024

Granulomatous hyperinflammatory state induced by dupilumab treatment for eosinophilic esophagitis.

Kanak V Kennedy, Anna Costello, Melissa A Lerman, Jon M Burnham, Aoife Corcoran, Joseph Piccione, Alexandra Grier, Kathleen Sullivan, Terri Whitehorn-Brown, Caitlin J Alexander and 3 more

Abstract readCase Reports
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kanak V KennedyDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pa.
Anna CostelloDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Melissa A LermanDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Jon M BurnhamDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Aoife CorcoranDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Joseph PiccioneDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Alexandra GrierDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Kathleen SullivanDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Terri Whitehorn-BrownDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
Caitlin J AlexanderDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pa.
Laura S FinnDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pa.
Benjamin J WilkinsDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pa.
Amanda B MuirDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pa.

Funding

Training Program in the Genetic Basis of Pediatric Gastrointestinal DisordersT32DK101371 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERT O HEUCKEROTH, Judith Rachel Kelsen · 2014 to 2026
$2.5M
NIDDK NIH HHS T32 DK101371
6 · The paper itself

Abstract

We present the first case of a dupilumab-induced hyperinflammatory state in the setting of underlying eosinophilic esophagitis characterized by multisystem granulomatous inflammation. Although clinical trial data and subsequent real-world experience support dupilumab as a highly effective therapy for eosinophilic esophagitis, close monitoring for development of adverse symptoms following initiation remains paramount.

Indexed as

adverse effectbiologicsDupilumabeosinophilic esophagitisgranuloma

Identifiers

PMID39253107
PMCPMC11382170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.